Htr7 5-hydroxytryptamine receptor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Htr7provided by RGD
Full Name: 5-hydroxytryptamine receptor 7provided by RGD
Primary source: RGD:71034
See related: EnsemblRapid:ENSRNOG00000018827 AllianceGenome:RGD:71034
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5Ht7
Summary: Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including axon terminus; neuronal cell body; and synaptic vesicle. Is active in postsynaptic membrane and presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 28.7), Spleen (RPKM 13.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (243049064..243173636, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (233636442..233761063, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (254547964..254671811, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats.
Title: Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats.
Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT7 Receptors.
Title: Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT(7) Receptors.
Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7 receptors inhibiting the tachycardic sympathetic drive in pithed rats.
Title: Blockade of 5-HT(2) receptors with sarpogrelate uncovers 5-HT(7) receptors inhibiting the tachycardic sympathetic drive in pithed rats.
The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction.
Title: The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction.
We analysed the modulation of capsaicin (CAP)-induced neurogenic inflammation in the rat hind paw by the selective 5-HT7 receptor agonist, LP-44, and the involvement of calcitonin gen-related peptide (CGRP) in this effect
Title: Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide.
Cross-talk inhibition occurs between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA pathway.
Title: Cross-talk inhibition between 5-HT(2B) and 5-HT(7) receptors in phrenic motor facilitation via NADPH oxidase and PKA.
Findings suggest that 5-HT7 receptor activation by AS19 improves synaptic dysfunction in a rat model of AD via reduction of apoptosis in the hippocampus and it could potentially prevent the progression of AD.
Title: The effects of the 5-HT7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of Alzheimer's disease.
Our data provide clear confirmation of the fact that recruitment of descending 5-HT neurons is required for voluntary locomotion in rodents, and that activation of 5-HT7 receptors is necessary for this effect.In addition, our results show that recruitment of descending 5-HT neurons acting through spinal 5-HT7 receptors is necessary for fictive locomotion evoked from the mesencephalic locomotor region.
Title: Serotonin controls initiation of locomotion and afferent modulation of coordination via 5-HT(7) receptors in adult rats.
Serotonin7 receptors in the lateral habenular nucleus regulate depressive-like behaviors in the hemiparkinsonian rats.
Title: Serotonin7 receptors in the lateral habenular nucleus regulate depressive-like behaviors in the hemiparkinsonian rats.
5-HT6/7 receptor antagonist ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
Title: ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.

Submit: New GeneRIF Correction See all GeneRIFs (46)

General gene information

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Markers

RH66814 (e-PCR)
- UniSTS:39426

HTR7 (e-PCR)
- UniSTS:511811

Htr7 (e-PCR), detects polymorphism
- UniSTS:511811

Htr7 (e-PCR), detects polymorphism
- UniSTS:143431

UniSTS:495969 (e-PCR)
- UniSTS:495969

Htr7 (e-PCR), detects polymorphism
- UniSTS:495969

RH143843 (e-PCR)
- UniSTS:233089

RH132467 (e-PCR)
- UniSTS:215750

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vein smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to corticosterone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 7

Names: 5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; GPRFO; high affinity serotonin receptor (5HT7); serotonin receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022938.2 → NP_075227.1 5-hydroxytryptamine receptor 7

Status: PROVISIONAL

Source sequence(s)

U68489

UniProtKB/TrEMBL

A0A0G2K0E3, A6I144

Related

ENSRNOP00000025450.6, ENSRNOT00000025450.9

Conserved Domains (2) summary

pfam00001
Location:101 → 387

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:101 → 222

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

243049064..243173636 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231307.4 → XP_006231369.1 5-hydroxytryptamine receptor 7 isoform X1

UniProtKB/Swiss-Prot

P32305, P97936

UniProtKB/TrEMBL

A0A8L2R8K1

Related

ENSRNOP00000082600.1, ENSRNOT00000111885.2

Conserved Domains (2) summary

pfam00001
Location:101 → 387

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:101 → 222

7tm_4; Olfactory receptor
XM_039089833.2 → XP_038945761.1 5-hydroxytryptamine receptor 7 isoform X2

Conserved Domains (2) summary

cd14964
Location:1 → 21

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039089840.2 → XP_038945768.1 5-hydroxytryptamine receptor 7 isoform X3

UniProtKB/TrEMBL

A0A0G2K5P0, P97842

Conserved Domains (1) summary

cd15329
Location:100 → 398

7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors