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    Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apbb1ipprovided by RGD
    Official Full Name
    amyloid beta precursor protein binding family B member 1 interacting proteinprovided by RGD
    Primary source
    RGD:1304795
    See related
    EnsemblRapid:ENSRNOG00000017803 AllianceGenome:RGD:1304795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Predicted to be part of T cell receptor complex. Predicted to be active in cytosol and plasma membrane. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 116.4), Spleen (RPKM 107.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apbb1ip in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (89849474..89941099)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (84941404..85033020)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90098953..90149192, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase 2 Neighboring gene uncharacterized LOC134482619 Neighboring gene decaprenyl diphosphate synthase subunit 1 Neighboring gene abl-interactor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrin activation. Banno A, et al. Biochem Soc Trans, 2008 Apr. PMID 18363565, Free PMC Article
    2. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Ménasché G, et al. Mol Cell Biol, 2007 Jun. PMID 17403904, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta A4 precursor protein-binding family B member 1-interacting protein
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100577.1 → NP_001094047.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein

      See identical proteins and their annotated locations for NP_001094047.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KS00, D3ZDZ1
      Related
      ENSRNOP00000024272.7, ENSRNOT00000024272.8
      Conserved Domains (2) summary
      cd01259
      Location:308 → 429
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16137
      Location:185 → 266
      RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      89849474..89941099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095818.2 → XP_038951746.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

      UniProtKB/TrEMBL
      A6KS00, D3ZDZ1
      Conserved Domains (2) summary
      cd01259
      Location:308 → 429
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16137
      Location:185 → 266
      RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

    2. XM_039095819.2 → XP_038951747.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2

      Conserved Domains (2) summary
      cd01259
      Location:156 → 277
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16137
      Location:33 → 114
      RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)
    Nucleotide Protein Strain
    Heading Accession and Version

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