Arsk arylsulfatase family, member K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arskprovided by RGD
Official Full Name: arylsulfatase family, member Kprovided by RGD
Primary source: RGD:1310182
See related: EnsemblRapid:ENSRNOG00000026937 AllianceGenome:RGD:1310182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310182
Summary: Predicted to enable arylsulfatase activity and glucuronate-2-sulfatase activity. Predicted to be located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis. Orthologous to human ARSK (arylsulfatase family member K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 87.2), Adrenal (RPKM 83.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (7306181..7363311, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (5574319..5631451, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (2835568..2891059, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylsulfatase activity	ISO Inferred from Sequence Orthology more info
enables arylsulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucuronate-2-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronate-2-sulfatase activity	ISO Inferred from Sequence Orthology more info
enables glucuronate-2-sulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arylsulfatase K

Names: ASK; glucuronate-2-sulfatase

NP_001041382.1

EC 3.1.6.1

EC 3.1.6.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.