Sry sex determining region Y [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sryprovided by RGD
Official Full Name: sex determining region Yprovided by RGD
Primary source: RGD:3759
See related: EnsemblRapid:ENSRNOG00000080005 AllianceGenome:RGD:3759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tdf; Tdy; Sry3B; SRYGENE
Summary: Enables enzyme binding activity and sequence-specific DNA binding activity. Involved in male sex determination and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: Yq11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	Y	NC_086040.1 (465260..465772)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	Y	NC_051357.1 (441525..442037)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	Y	NC_024475.1 (327176..327685)

Chromosome Y - NC_086040.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRY directs a previously unrecognized male-specific mechanism of dopaminergic neuron cell death.
Title: Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson's disease.
Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
Title: Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
These results suggest that SRY regulation of the renin-angiotensin system is partially shared with its X-chromosome homolog SOX3.
Title: Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.
Data show that Sry is involved in male-specific malignant conversion of rodent hepatocellular carcinoma via Sgf29 upregulation.
Title: The male-specific factor Sry harbors an oncogenic function.
Data suggest that Sry and Tcf21 (transcription factor 21) induce initial stages of embryonic Sertoli cell differentiation; Scx (scleraxis) induces later stages. This cascade--Sry>Tcf21>Scx--appears to promote subsequent sex differentiation.
Title: SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats.
The specific DNA sequence binding site motifs for both SRY and SOX9 were identified.
Title: Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9.
Observations suggest that SRY physically interacts with the Ntf3 promoter during male sex determination to coordinate cell migration in the testis to form testis cords.
Title: SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats.
The current study identifies one of the first direct downstream targets of the male sex determining factor SRY as the basic-helix-loop-helix (bHLH) transcription factor TCF21.
Title: Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY.
These actions of Sry could result in increased blood pressure in males and contribute to sex differences in blood pressure.
Title: Regulation of multiple renin-angiotensin system genes by Sry.
The Sry loci is the hypertensive component of the SHR Y chromosome.
Title: Which Sry locus is the hypertensive Y chromosome locus?

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Sry (e-PCR), detects polymorphism
- UniSTS:464694

PMC303372P2 (e-PCR)
- UniSTS:272519

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding, bending	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male sex determination	IBA Inferred from Biological aspect of Ancestor more info
involved_in male sex determination	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within male sex determination	ISO Inferred from Sequence Orthology more info
involved_in male sex determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sex determination	ISO Inferred from Sequence Orthology more info
involved_in sex determination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sex-determining region Y protein

Names: Testis determining locus; sex determining region of Chr Y; sex determining region on Y; sex-determining region Y protein 3B; testis-determining factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416740.1 → NP_001403669.1 sex-determining region Y protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000022

UniProtKB/TrEMBL

Q811V4, Q811V5

Related

ENSRNOP00000109086.1, ENSRNOT00000146995.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086040.1 Reference GRCr8

Range

465260..465772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_012772.1: Suppressed sequence

Description

NM_012772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.