Tfb2m transcription factor B2, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tfb2mprovided by RGD
Full Name: transcription factor B2, mitochondrialprovided by RGD
Primary source: RGD:1307091
See related: EnsemblRapid:ENSRNOG00000002695 AllianceGenome:RGD:1307091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 193.3), Muscle (RPKM 177.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (93810859..93828678, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (91278889..91296709, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (97820493..97838275, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription in cardiac myocytes.
Title: Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.

Submit: New GeneRIF Correction

General gene information

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Markers

Tfb2m (e-PCR), detects polymorphism
- UniSTS:496732

RH131657 (e-PCR)
- UniSTS:214940

RH129620 (e-PCR)
- UniSTS:212917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mitochondrial transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial transcription factor activity	ISO Inferred from Sequence Orthology more info
enables mitochondrial transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at mitochondrial promoter	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at mitochondrial promoter	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dimethyladenosine transferase 2, mitochondrial

Names: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; dimethyladenosine transferase 2, mitochondrial-like; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2; mtTFB2

NP_001008294.1

EC 2.1.1.-

XP_008768039.1

EC 2.1.1.-

XP_038946480.1

EC 2.1.1.-

XP_038946481.1

EC 2.1.1.-

XP_063128234.1

EC 2.1.1.-

XP_063128235.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008293.1 → NP_001008294.1 dimethyladenosine transferase 2, mitochondrial

See identical proteins and their annotated locations for NP_001008294.1

Status: PROVISIONAL

Source sequence(s)

BC085870

UniProtKB/Swiss-Prot

Q5U2T7

UniProtKB/TrEMBL

A6JGF4

Related

ENSRNOP00000003618.3, ENSRNOT00000003618.5

Conserved Domains (1) summary

cl17173
Location:82 → 378

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

93810859..93828678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090552.2 → XP_038946480.1 dimethyladenosine transferase 2, mitochondrial isoform X3

Conserved Domains (1) summary

cl17173
Location:84 → 270

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_008769817.4 → XP_008768039.1 dimethyladenosine transferase 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZY51

Related

ENSRNOP00000084899.1, ENSRNOT00000086734.3

Conserved Domains (1) summary

cl17173
Location:84 → 266

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063272164.1 → XP_063128234.1 dimethyladenosine transferase 2, mitochondrial isoform X2
XM_039090553.2 → XP_038946481.1 dimethyladenosine transferase 2, mitochondrial isoform X4

Conserved Domains (1) summary

cl17173
Location:84 → 266

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063272165.1 → XP_063128235.1 dimethyladenosine transferase 2, mitochondrial isoform X4