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    Il3 interleukin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24495, updated on 4-Jan-2025

    Summary

    Official Symbol
    Il3provided by RGD
    Official Full Name
    interleukin 3provided by RGD
    Primary source
    RGD:2897
    See related
    EnsemblRapid:ENSRNOG00000026786 AllianceGenome:RGD:2897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Il3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38906460..38908810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38405716..38408066, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39620535..39622973, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene casein kinase 2 alpha 1, pseudogene 1 Neighboring gene colony stimulating factor 2 Neighboring gene uncharacterized LOC120095100 Neighboring gene acyl-CoA synthetase long-chain family member 6 Neighboring gene uncharacterized LOC120095099

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity  
    enables interleukin-3 receptor binding  
    enables interleukin-3 receptor binding PubMed 
    enables interleukin-3 receptor binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process  
    acts_upstream_of B cell proliferation  
    acts_upstream_of JNK cascade  
    acts_upstream_of T cell proliferation  
    acts_upstream_of_or_within activation of Janus kinase activity  
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor signaling pathway via STAT  
    acts_upstream_of_or_within cytokine-mediated signaling pathway  
    involved_in embryonic hemopoiesis  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of hematopoietic progenitor cell differentiation  
    involved_in hemopoiesis PubMed 
    involved_in immune response  
    acts_upstream_of_or_within interleukin-3-mediated signaling pathway  
    involved_in interleukin-3-mediated signaling pathway  
    acts_upstream_of mast cell apoptotic process  
    acts_upstream_of mast cell proliferation  
    acts_upstream_of_or_within monocyte differentiation  
    acts_upstream_of myeloid cell apoptotic process  
    acts_upstream_of_or_within myeloid cell apoptotic process  
    acts_upstream_of myeloid leukocyte differentiation  
    acts_upstream_of_or_within negative regulation of B cell apoptotic process  
    acts_upstream_of_or_within negative regulation of autophagy  
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process  
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process  
    acts_upstream_of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of B cell proliferation  
    acts_upstream_of_or_within positive regulation of JNK cascade  
    acts_upstream_of_or_within positive regulation of T cell proliferation  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation  
    acts_upstream_of_or_within positive regulation of mast cell proliferation  
    acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    acts_upstream_of_or_within protein dephosphorylation  
    acts_upstream_of protein phosphorylation  
    involved_in regulation of cell growth PubMed 
    acts_upstream_of_or_within regulation of cell growth  
    acts_upstream_of_or_within regulation of gene expression  
    acts_upstream_of_or_within regulation of glycolytic process  
    involved_in response to hormone PubMed 
    acts_upstream_of_or_within response to hypoxia  
    involved_in signal transduction  
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    interleukin-3
    Names
    IL-3
    MCGF
    P-cell-stimulating factor
    hematopoietic growth factor
    mast cell growth factor
    multipotential colony-stimulating factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429896.1NP_001416825.1  interleukin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P04823, P70513
      UniProtKB/TrEMBL
      A6HEH2
    2. NM_031513.3NP_113701.2  interleukin-3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LS41, P97688
      Related
      ENSRNOP00000030704.1, ENSRNOT00000031762.3
      Conserved Domains (1) summary
      pfam02059
      Location:34140
      IL3; Interleukin-3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38906460..38908810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246226.4XP_006246288.1  interleukin-3 isoform X1

      Conserved Domains (1) summary
      pfam02059
      Location:31134
      IL3; Interleukin-3
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