CycB Cyclin B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycBprovided by FlyBase
Official Full Name: Cyclin Bprovided by FlyBase
Primary source: FLYBASE:FBgn0000405
Locus tag: Dmel_CG3510
See related: AllianceGenome:FB:FBgn0000405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2g; 3510; CG3510; chr2R:18312808..18312907; cyc B; Cyc B; cyc-B; CYC-B; cycb; cycB; Cycb; CYCB; cyclin B; CYCLIN B; Cyclin B1; cyclinB; cyclinB1; DmcycB; Dmel\CG3510; mAbF2F4
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G2/M transition of mitotic cell cycle; midbody abscission; and nuclear chromosome segregation. Located in nucleus and spindle midzone. Colocalizes with mitotic spindle. Is expressed in several structures, including antennal primordium; ganglia; germline cell; head epidermis primordium; and optic neuroblast. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to several human genes including CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59B2-59B2; 2-101 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22803521..22806948, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18691026..18694453, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis.
Title: Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis.
Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males.
Title: Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males.
Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins.
Title: Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins.
Cyclin B1-Cdk1 localized at the spindle midzone in an Aurora B-dependent manner, with incompletely separated chromosomes showing the highest Cdk1 activity. Slowing down anaphase chromosome motion delayed Cyclin B1 degradation and mitotic exit in an Aurora B-dependent manner.
Title: Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
During meiotic prophase in Drosophila males, transcript for the core cell cycle protein Cyclin B1 (CycB) is expressed in spermatocytes, but the protein does not accumulate in spermatocytes until just before the meiotic divisions.
Title: Cell type-specific translational repression of Cyclin B during meiosis in males.
We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Title: Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells.
dFMRP and Caprin collaborate to control the cell cycle at the MBT by directly mediating the normal repression of maternal Cyclin B mRNA and the activation of zygotic fruhstart mRNA.
Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
induced by myb in eye imaginal disc
Title: Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc.
CycB is required for the division of germline stem cells and their precursors.
Title: The division of Drosophila germline stem cells and their precursors requires a specific cyclin.
These data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
Title: The Drosophila PNG kinase complex regulates the translation of cyclin B.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	TAS Traceable Author Statement more info	PubMed
involved_in germ-line cyst formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbody abscission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome movement towards spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatocyte division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	TAS Traceable Author Statement more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin B

Names: CG3510-PA; CG3510-PB; CG3510-PC; CG3510-PE; CycB PRE/TRE element; CycB-PA; CycB-PB; CycB-PC; CycB-PE; Cyclin-B; cyclin B1; cyclinB; dCyclinB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22803521..22806948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166556.3 → NP_726245.2 cyclin B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726245.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P20439

Conserved Domains (2) summary

pfam00134
Location:258 → 385

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:387 → 513

Cyclin_C; Cyclin, C-terminal domain
NM_166555.3 → NP_726244.1 cyclin B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726244.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20439, Q0E8Y2, Q8MME2, Q9I7V2, Q9TYH6, Q9TYH7, Q9V3F4

Related

FBpp0071822

Conserved Domains (2) summary

pfam00134
Location:260 → 387

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:389 → 515

Cyclin_C; Cyclin, C-terminal domain
NM_166557.3 → NP_726246.1 cyclin B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726246.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QPI9

Related

FBpp0071824

Conserved Domains (2) summary

pfam00134
Location:254 → 381

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:383 → 509

Cyclin_C; Cyclin, C-terminal domain
NM_166558.2 → NP_726247.1 cyclin B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726247.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20439

Related

FBpp0071825

Conserved Domains (2) summary

pfam00134
Location:230 → 357

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:359 → 485

Cyclin_C; Cyclin, C-terminal domain