U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pcx pecanex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31204, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pcxprovided by FlyBase
    Official Full Name
    pecanexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003048
    Locus tag
    Dmel_CG3443
    See related
    AllianceGenome:FB:FBgn0003048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3443; Dmel\CG3443; DMPCX; EG:30B8.4; fs(1)12-1012; fs(1)12-1743; fs(1)12-2135; fs(1)12-3014; fs(1)12-3102; fs(1)12-4169; fs(1)14-1153; fs(1)14-567; fs(1)A387; fs(1)M10; fs(1)pcx; mel(1)R; mel(1)R1
    Summary
    Involved in endoplasmic reticulum organization. Located in endoplasmic reticulum. Is expressed in organism. Orthologous to several human genes including PCNX3 (pecanex 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pcx in Genome Data Viewer
    Location:
    2F1-2F1; 1-0.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2225296..2238045)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2119329..2132078)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vinculin Neighboring gene uncharacterized protein Neighboring gene kurz Neighboring gene female sterile (1) K10 Neighboring gene Odorant receptor 2a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differentiation in vitro of neural precursor cells from normal and Pecanex mutant Drosophila embryos. LaBonne SG, et al. J Neurogenet, 1989 May. PMID 2500508
    2. A mammalian homologue of a transcript from the Drosophila pecanex locus. Gilbert TL, et al. J Neurogenet, 1992 Sep. PMID 1460533
    3. Maternally influenced embryonic lethality: allele specific genetic rescue at a female fertility locus in Drosophila melanogaster. Romans P, et al. Can J Genet Cytol, 1976 Dec. PMID 828515
    4. Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein. LaBonne SG, et al. Dev Biol, 1989 Nov. PMID 2478400
    5. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. LaBonne SG, et al. Dev Biol, 1985 Jul. PMID 4007265

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic screens study identified dominant modifiers of the cold-sensitive lethality associated with a pcx mutation condition.
      Title: Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila.
    2. It was shown that pecanex is a component of the Notch-signaling pathway. Pecanex was required upstream of the membrane-tethered and the nuclear forms of activated Notch protein.
      Title: Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pecanex
    Names
    CG3443-PC
    CG3443-PE
    CG3443-PF
    pcx-PC
    pcx-PE
    pcx-PF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2225296..2238045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272254.2 → NP_001259183.2  pecanex, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259183.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGU2
      Conserved Domains (2) summary
      pfam05041
      Location:2523 → 2746
      Pecanex_C; Pecanex protein (C-terminus)
      pfam15847
      Location:2779 → 2842
      Loricrin; Major keratinocyte cell envelope protein

    2. NM_001272253.1 → NP_001259182.1  pecanex, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46074, P18490, Q95TI6, Q9W506
      UniProtKB/TrEMBL
      M9PGB7
      Conserved Domains (2) summary
      pfam05041
      Location:2519 → 2742
      Pecanex_C; Pecanex protein (C-terminus)
      pfam15847
      Location:2775 → 2838
      Loricrin; Major keratinocyte cell envelope protein

    3. NM_080306.4 → NP_525045.3  pecanex, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525045.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46074, P18490, Q95TI6, Q9W506
      UniProtKB/TrEMBL
      M9PGB7
      Conserved Domains (2) summary
      pfam05041
      Location:2519 → 2742
      Pecanex_C; Pecanex protein (C-terminus)
      pfam15847
      Location:2775 → 2838
      Loricrin; Major keratinocyte cell envelope protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGB7 M9PGB7
    M9PGU2 M9PGU2
    P18490.4 P18490

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools