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    Zip88E Zinc/iron regulated transporter-related protein 88E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zip88Eprovided by FlyBase
    Official Full Name
    Zinc/iron regulated transporter-related protein 88Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038312
    Locus tag
    Dmel_CG4334
    See related
    AllianceGenome:FB:FBgn0038312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4334; CG4334; Dmel\CG4334; dZip88E; ZIP88E
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Located in basolateral plasma membrane. Is expressed in adult head and organism. Orthologous to human SLC39A1 (solute carrier family 39 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zip88E in Genome Data Viewer
    Location:
    88E9-88E9; 3-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15268662..15270532)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11094384..11096254)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Set Neighboring gene ATP synthase, oligomycin sensitivity conferring protein Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 190kD Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene MORF-related gene 15 Neighboring gene lethal (3) neo43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. Lye JC, et al. J Biol Inorg Chem, 2013 Mar. PMID 23322169
    2. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Pai CY, et al. Mol Cell, 2004 Dec 3. PMID 15574329
    3. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Dechen K, et al. Int J Biochem Cell Biol, 2015 Mar. PMID 25562517
    4. A role for the Drosophila zinc transporter Zip88E in protecting against dietary zinc toxicity. Richards CD, et al. PLoS One, 2017. PMID 28704512, Free PMC Article
    5. What can flies tell us about zinc homeostasis? Xiao G, et al. Arch Biochem Biophys, 2016 Dec 1. PMID 27136711

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc/iron regulated transporter-related protein 88E
    Names
    CG4334-PB
    Zip88E-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15268662..15270532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142183.3 → NP_650440.2  Zinc/iron regulated transporter-related protein 88E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650440.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFA2
      Conserved Domains (1) summary
      pfam02535
      Location:26 → 359
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NR13 Q6NR13
    Q9VFA2 Q9VFA2

    Gene LinkOut

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