ssh slingshot [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sshprovided by FlyBase
Official Full Name: slingshotprovided by FlyBase
Primary source: FLYBASE:FBgn0029157
Locus tag: Dmel_CG6238
See related: AllianceGenome:FB:FBgn0029157
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6238; Dmel\CG6238; l(3)01207; MKP; Mkph; Ssh; SSH
Summary: Enables actin binding activity and phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of actin filament polymerization; nervous system development; and regulation of plasma membrane bounded cell projection organization. Located in apical part of cell. Is expressed in eye disc; larval central nervous system; larval ventral nerve cord; and photoreceptor neurons. Used to study alcohol use disorder. Orthologous to several human genes including SSH1 (slingshot protein phosphatase 1) and SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96B10-96B11; 3-86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24938710..24944956, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20764432..20770678, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In mature neurons SSH may function as a stabilization factor for filamentous actin instead of promoting actin depolymerization.
Title: Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.
we found that Capt(Capulet) and Ssh(Slingshot), but not Tsr, share overlapping functions during eye morphogenesis
Title: Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis.
Ssh acts in the developing eye to limit actin polymerization in the assembling ommatidia, but not in the morphogenetic furrow.
Title: Slingshot cofilin phosphatase localization is regulated by receptor tyrosine kinases and regulates cytoskeletal structure in the developing Drosophila eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables MAP kinase tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables MAP kinase tyrosine/serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: slingshot

Names: CG6238-PA; CG6238-PB; CG6238-PC; CG6238-PD; MAP-kinase-phosphatase; MKP-like; ssh-PA; ssh-PB; ssh-PC; ssh-PD

NP_001163716.1

EC 3.1.3.-

NP_001163717.1

EC 3.1.3.-

NP_524492.2

EC 3.1.3.-

NP_733063.1

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24938710..24944956 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079768.4 → NP_524492.2 slingshot, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524492.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NN85

Related

FBpp0084174

Conserved Domains (3) summary

cd11652
Location:3 → 312

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:384 → 518

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:327 → 378

DEK_C; DEK C terminal domain
NM_001170246.1 → NP_001163717.1 slingshot, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163717.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NN85, Q7KS05, Q8IMU8, Q9NKY1, Q9VC04

UniProtKB/TrEMBL

D3PFH9

Conserved Domains (3) summary

cd11652
Location:3 → 312

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:384 → 518

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:327 → 378

DEK_C; DEK C terminal domain
NM_001170245.1 → NP_001163716.1 slingshot, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163716.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIW2

Conserved Domains (3) summary

cd11652
Location:21 → 313

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:385 → 519

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:328 → 379

DEK_C; DEK C terminal domain
NM_170184.2 → NP_733063.1 slingshot, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733063.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NN85

Related

FBpp0084175

Conserved Domains (3) summary

cd11652
Location:21 → 313

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:385 → 519

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:328 → 379

DEK_C; DEK C terminal domain