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    Hs3st-B Heparan sulfate 3-O sulfotransferase-B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st-Bprovided by FlyBase
    Official Full Name
    Heparan sulfate 3-O sulfotransferase-Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031005
    Locus tag
    Dmel_CG7890
    See related
    AllianceGenome:FB:FBgn0031005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7890; dHS3OSTB; dHs3st-B; Dmel\CG7890; HS3ST
    Summary
    Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Human ortholog(s) of this gene implicated in colon cancer; hereditary angioedema; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to several human genes including HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hs3st-B in Genome Data Viewer
    Location:
    18B5-18B6; 1-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19248639..19252045)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19142672..19146078)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene rapamycin-insensitive companion of Tor Neighboring gene Vav guanine nucleotide exchange factor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling. Guo Y, et al. J Genet Genomics, 2014 Jul 20. PMID 25064676
    2. Glycosyltransferases and transporters that contribute to proteoglycan synthesis in Drosophila: Identification and functional analyses using the heritable and inducible RNAi system. Nishihara S. Methods Enzymol, 2010. PMID 20816216
    3. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. Goda E, et al. J Biol Chem, 2006 Sep 29. PMID 16873373
    4. Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies. Ueyama M, et al. J Biol Chem, 2008 Mar 7. PMID 18165227
    5. Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut. Guo Y, et al. Cell Signal, 2014 Nov. PMID 25049075

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that Drosophila Hs3st-A and Hs3st-B are involved in the regulation of ISC proliferation and midgut homeostasis maintenance.
      Title: Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut.
    2. Hs3st-B mutant flies did not alter the expression of Notch signaling components
      Title: Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heparan sulfate 3-O sulfotransferase-B
    Names
    3-O-sulfotransferase
    CG7890-PA
    CG7890-PB
    Hs3st-B-PA
    Hs3st-B-PB
    NP_001259702.1
    NP_573370.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19248639..19252045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272773.2 → NP_001259702.1  heparan sulfate 3-O sulfotransferase-B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWJ7
      Conserved Domains (1) summary
      pfam00685
      Location:131 → 368
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_133142.2 → NP_573370.1  heparan sulfate 3-O sulfotransferase-B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWJ7
      Related
      FBpp0074447
      Conserved Domains (1) summary
      pfam00685
      Location:131 → 368
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWJ7 Q9VWJ7

    Gene LinkOut

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