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    Slimp Seryl-tRNA synthetase-like insect mitochondrial protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slimpprovided by FlyBase
    Official Full Name
    Seryl-tRNA synthetase-like insect mitochondrial proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051133
    Locus tag
    Dmel_CG31133
    See related
    AllianceGenome:FB:FBgn0051133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD24627; CG31133; Dmel\CG31133; SLIMP
    Summary
    Enables tRNA binding activity. Contributes to serine-tRNA ligase activity. Involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Part of serine-tRNA ligase complex. Is expressed in several structures, including anlage in statu nascendi; anterior endoderm anlage; central brain anlage in statu nascendi; dorsal pharyngeal muscle cell; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slimp in Genome Data Viewer
    Location:
    95E5-95E5; 3-83 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24147436..24148967, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19973158..19974689, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 10 Neighboring gene Niemann-Pick type C-2f Neighboring gene Kallmann syndrome 1 Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease. Dulic M, et al. Life (Basel), 2024 Jan 15. PMID 38255739, Free PMC Article
    2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
    3. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
    4. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Liu X, et al. Cell Rep, 2015 Dec 15. PMID 26673323, Free PMC Article
    5. Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Ambrus AM, et al. Genetics, 2009 Sep. PMID 19546319, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A duplication of the gene coding for mitochondrial seryl-tRNA synthetase (SerRS2) generated in arthropods a paralog protein (SLIMP) that forms a heterodimeric complex with a SerRS2 monomer.
      Title: Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit.
    2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function
      Title: New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to serine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine-tRNA ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Seryl-tRNA synthetase-like insect mitochondrial protein
    Names
    CG31133-PA
    Slimp-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24147436..24148967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170125.3 → NP_732958.1  Seryl-tRNA synthetase-like insect mitochondrial protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95T19
      Related
      FBpp0083968
      Conserved Domains (3) summary
      TIGR00414
      Location:43 → 433
      serS; seryl-tRNA synthetase
      cl00268
      Location:194 → 433
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
      cl12057
      Location:51 → 150
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95T19.1 Q95T19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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