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    Sap130 Sin3A-associated protein 130 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sap130provided by FlyBase
    Official Full Name
    Sin3A-associated protein 130provided by FlyBase
    Primary source
    FLYBASE:FBgn0262714
    Locus tag
    Dmel_CG11006
    See related
    AllianceGenome:FB:FBgn0262714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21213; CG11006; Dmel\CG11006; l(3)06924; SAP130
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3-type complex. Is expressed in several structures, including adult brain cell body rind; epithelial tube; gland; larval brain; and ring gland. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sap130 in Genome Data Viewer
    Location:
    69E4-69E4; 3-39 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12805902..12813036)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12799002..12806136)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46251 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3a subunit 2 Neighboring gene nebulosa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Edwards AC, et al. Genetics, 2009 Jul. PMID 19414563, Free PMC Article
    2. Rapid clearance of epigenetic protein reporters from wound edge cells in Drosophila larvae does not depend on the JNK or PDGFR/VEGFR signaling pathways. Anderson AE, et al. Regeneration (Oxf), 2014 Apr 1. PMID 25114797, Free PMC Article
    3. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Barnes VL, et al. Sci Rep, 2018 Nov 19. PMID 30451916, Free PMC Article
    4. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Chen GC, et al. Autophagy, 2008 Jan. PMID 17952025
    5. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. Spain MM, et al. J Biol Chem, 2010 Aug 27. PMID 20566628, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Sin3A-associated protein 130
    Names
    CG11006-PA
    CG11006-PB
    CG11006-PC
    CG11006-PE
    CG11006-PF
    CG11006-PG
    Sap130-PA
    Sap130-PB
    Sap130-PC
    Sap130-PE
    Sap130-PF
    Sap130-PG
    Sin3A-Associated protein
    lethal (3) 06924

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12805902..12813036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168517.3 → NP_729834.1  Sin3A-associated protein 130, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM9, Q8IQI0
      Related
      FBpp0075661
      Conserved Domains (1) summary
      pfam16014
      Location:1138 → 1275
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    2. NM_168518.3 → NP_729835.1  Sin3A-associated protein 130, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN3, Q7KUI5, Q8IQH9
      Related
      FBpp0075660
      Conserved Domains (1) summary
      pfam16014
      Location:1073 → 1238
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    3. NM_140345.4 → NP_648602.1  Sin3A-associated protein 130, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN3, Q9XZ09
      Related
      FBpp0075659
      Conserved Domains (1) summary
      pfam16014
      Location:1063 → 1200
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    4. NM_001274855.1 → NP_001261784.1  Sin3A-associated protein 130, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN3, M9PCC4
      Conserved Domains (1) summary
      pfam16014
      Location:1054 → 1191
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    5. NM_001274854.1 → NP_001261783.1  Sin3A-associated protein 130, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN3, M9PI47
      Conserved Domains (1) summary
      pfam16014
      Location:1053 → 1190
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    6. NM_168519.2 → NP_729836.3  Sin3A-associated protein 130, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729836.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN3, Q7KUI5, Q8IQH9
      Conserved Domains (1) summary
      pfam16014
      Location:1073 → 1238
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCC4 M9PCC4
    M9PI47 M9PI47
    Q8IQH9 Q8IQH9
    Q8IQI0 Q8IQI0
    Q9XZ09 Q9XZ09

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