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    SoYb Sister of Yb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SoYbprovided by FlyBase
    Official Full Name
    Sister of Ybprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051755
    Locus tag
    Dmel_CG31755
    See related
    AllianceGenome:FB:FBgn0051755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31755; CG5831; Dmel\CG31755; soyb
    Summary
    Predicted to enable RNA helicase activity. Involved in primary piRNA processing and secondary piRNA processing. Located in Yb body and cytosol. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SoYb in Genome Data Viewer
    Location:
    30F5-30F5; 2-38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9996706..10002736, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9996706..10002736, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L13 Neighboring gene long non-coding RNA:CR13130 Neighboring gene big brain Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44873 Neighboring gene Nucleosome-destabilizing factor Neighboring gene Translocation protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia. Fort-Aznar L, et al. Hum Mol Genet, 2020 Sep 29. PMID 32628265, Free PMC Article
    2. Requirements for multivalent Yb body assembly in transposon silencing in Drosophila. Hirakata S, et al. EMBO Rep, 2019 Jul. PMID 31267711, Free PMC Article
    3. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. Szakmary A, et al. J Cell Biol, 2009 May 18. PMID 19433453, Free PMC Article
    4. piRNAs as Modulators of Disease Pathogenesis. Rayford KJ, et al. Int J Mol Sci, 2021 Feb 27. PMID 33673453, Free PMC Article
    5. Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation. Yamashiro H, et al. EMBO Rep, 2020 Feb 5. PMID 31833223, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
      Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ-line stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary piRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in primary piRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in secondary piRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sister of Yb
    Names
    CG31755-PB
    CG31755-PC
    SoYb-PB
    SoYb-PC
    NP_001245959.1
    NP_609335.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9996706..10002736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259030.2 → NP_001245959.1  sister of Yb, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E0R964, Q9VL52
      Conserved Domains (3) summary
      COG0513
      Location:475 → 877
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:927 → 1043
      TUDOR; Tudor domain
      cl21455
      Location:480 → 646
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_135491.5 → NP_609335.3  sister of Yb, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609335.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E0R964, Q9VL52
      Conserved Domains (3) summary
      COG0513
      Location:475 → 877
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:927 → 1043
      TUDOR; Tudor domain
      cl21455
      Location:480 → 646
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL52.3 Q9VL52

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