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    Gyc89Da Guanylyl cyclase at 89Da [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gyc89Daprovided by FlyBase
    Official Full Name
    Guanylyl cyclase at 89Daprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038435
    Locus tag
    Dmel_CG14885
    See related
    AllianceGenome:FB:FBgn0038435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14885; Dmel\CG14885; Gyc-89Da; GYCb
    Summary
    Enables enzyme binding activity and guanylate cyclase activity. Involved in nitric oxide-cGMP-mediated signaling; response to hypoxia; and response to reactive oxygen species. Part of guanylate cyclase complex, soluble. Is expressed in anterior wing margin; chemosensory neurons; labellum; and tarsal segment. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gyc89Da in Genome Data Viewer
    Location:
    89B17-89B17; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16472601..16475477)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12298323..12301199)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 5 Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Dihydrofolate reductase Neighboring gene Succinate dehydrogenase assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atypical soluble guanylyl cyclases control brain size in Drosophila. Prieto D, et al. MicroPubl Biol, 2024. PMID 39185012, Free PMC Article
    2. Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases. Vermehren-Schmaedick A, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2011 Jul. PMID 21350862
    3. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. Morton DB. J Biol Chem, 2004 Dec 3. PMID 15485853
    4. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. Morton DB, et al. J Insect Sci, 2005. PMID 16341244, Free PMC Article
    5. Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster. Langlais KK, et al. J Exp Biol, 2004 Jun. PMID 15159437

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gyc-89Da only forms an active guanylyl cyclase when co-expressed with Gyc-88E.
      Title: Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanylate cyclase complex, soluble IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of guanylate cyclase complex, soluble IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylyl cyclase at 89Da
    Names
    CG14885-PB
    CG14885-PC
    Gyc89Da-PB
    Gyc89Da-PC
    NP_001036718.1
    NP_001036719.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16472601..16475477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043254.2 → NP_001036719.1  guanylyl cyclase at 89Da, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI63, Q4V501, Q9VEU6
      UniProtKB/TrEMBL
      B7Z0S6
      Conserved Domains (4) summary
      smart00044
      Location:457 → 643
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:485 → 662
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 161
      HNOB; Haem-NO-binding
      pfam07701
      Location:218 → 476
      HNOBA; Heme NO binding associated

    2. NM_001043253.1 → NP_001036718.1  guanylyl cyclase at 89Da, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI63, Q4V501, Q9VEU6
      UniProtKB/TrEMBL
      B7Z0S6
      Conserved Domains (4) summary
      smart00044
      Location:457 → 643
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:485 → 662
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 161
      HNOB; Haem-NO-binding
      pfam07701
      Location:218 → 476
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0S6 B7Z0S6
    Q9VEU6.2 Q9VEU6

    Gene LinkOut

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