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    Takl1 Tak1-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318725, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Takl1provided by FlyBase
    Official Full Name
    Tak1-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0046689
    Locus tag
    Dmel_CG31421
    See related
    AllianceGenome:FB:FBgn0046689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003732.1; CG31421; Dmel\CG31421; FBgn0046689; takl1; TAKL1
    Summary
    Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade; immune response; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Takl1 in Genome Data Viewer
    Location:
    92F13-92F13; 3-69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20770828..20772601, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16596550..16598323, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha4 subunit, Testis-specific 1 Neighboring gene uncharacterized protein Neighboring gene Syncrip Neighboring gene Fancd2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Cancer Models Identify Functional Differences between Ret Fusions. Levinson S, et al. Cell Rep, 2016 Sep 13. PMID 27626672, Free PMC Article
    2. Association of Wolbachia with Gene Expression in Drosophila Testes. Dou W, et al. Microb Ecol, 2021 Oct. PMID 33555369
    3. A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Lesch C, et al. Genetics, 2010 Nov. PMID 20813879, Free PMC Article
    4. JNK signaling is needed to tolerate chromosomal instability. Wong HW, et al. Cell Cycle, 2014. PMID 24335260, Free PMC Article
    5. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Tak1-like 1
    Names
    CG31421-PA
    Takl1-PA
    extra2
    NP_732554.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20770828..20772601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169924.3 → NP_732554.1  Tak1-like 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83104, Q4V4Q1
      UniProtKB/TrEMBL
      Q4V4A7
      Related
      FBpp0083400
      Conserved Domains (2) summary
      smart00220
      Location:15 → 262
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14058
      Location:17 → 274
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83104.1 P83104

    Gene LinkOut

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