DIP1 DISCO Interacting Protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DIP1provided by FlyBase
Official Full Name: DISCO Interacting Protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0024807
Locus tag: Dmel_CG17686
See related: AllianceGenome:FB:FBgn0024807
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17686; clot 10495; clot 2020; dip1; dip1a; Dmel\CG17686; klt; TO34; TO67; UbxBP1
Summary: Enables RNA binding activity. Involved in RNA catabolic process; germ-line stem-cell niche homeostasis; and response to virus. Located in cytoplasm and nucleus. Is active in nuclear body. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 20A4-20A5; 1-66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (21624796..21630148, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (21495823..21501175, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the pre-mRNA destabilization caused by Dsn depletion is rescued in DIP1 or Sumo heterozygous mutants, suggesting that Dsn is a negative regulator of DIP1. Our results reveal that under normal circumstances nascent transcripts are susceptible to DIP1-mediated degradation, however intronic sequences are protected by Dsn until intron excision has taken place
Title: SON protects nascent transcripts from unproductive degradation by counteracting DIP1.
The RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.
Title: DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.
demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo
Title: DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster.
DIP1-c was shown to interact with ADAT, a tRNA deaminase that presumably modifies pre-tRNAs.
Title: Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT.
the longest isoform of this protein, DIP1-c, exhibits a 500-fold preference for dsRNA over dsDNA of similar nucleotide sequence.
Title: High affinity, dsRNA binding by disconnected interacting protein 1.
Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].
the flamenco- phenotype may be associated with an alteration of DIP1 gene transcription, as in differentflamenco- strains the DIP1 gene expression is changed differently.
Title: [Analysis of the structure and expression of the DIP1 gene in Drosophila melanogaster strains mutant for the flamenco gene].
L27a protein, via interaction with DIP1, could be involved in protein synthesis as well as in cell cycle regulation
Title: Identification of a cDNA clone encoding DIP1-binding protein in Drosophila melanogaster.
disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development.
Title: A novel double-stranded RNA-binding protein, disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development.
Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein
Title: Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA intronic binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables siRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lncRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-mRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of regulatory ncRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RISC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC-loading complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DISCO interacting protein 1

Names: CG17686-PB; CG17686-PC; CG17686-PD; CG17686-PE; CG17686-PF; CG17686-PG; CG17686-PH; CG17686-PI; DIP1-PB; DIP1-PC; DIP1-PD; DIP1-PE; DIP1-PF; DIP1-PG; DIP1-PH; DIP1-PI; Disco-interacting protein 1; Disconnected-interacting protein 1; disconnected interacting protein 1; klett; ultrabithorax binding protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

21624796..21630148 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169345.2 → NP_001162816.1 DISCO interacting protein 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162816.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NIH3, Q9TW12

Conserved Domains (1) summary

cd00048
Location:71 → 130

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_079929.3 → NP_524668.2 DISCO interacting protein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524668.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U4F5, Q9U6N4

Related

FBpp0077064

Conserved Domains (1) summary

cd00048
Location:157 → 216

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_167772.2 → NP_728449.1 DISCO interacting protein 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728449.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NHW9, Q9TW27

Related

FBpp0077065

Conserved Domains (1) summary

cd00048
Location:172 → 231

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_001169346.2 → NP_001162817.1 DISCO interacting protein 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162817.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MRC7, Q9NIH3

Conserved Domains (1) summary

cd00048
Location:140 → 199

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_167774.3 → NP_728451.2 DISCO interacting protein 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728451.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9GNA3, Q9W5S7

Conserved Domains (1) summary

cd00048
Location:156 → 215

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_167773.3 → NP_728450.1 DISCO interacting protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728450.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4V2, Q9GND0

Related

FBpp0077063

Conserved Domains (1) summary

cd00048
Location:171 → 230

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_001169343.2 → NP_001162814.1 DISCO interacting protein 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162814.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MRC7, Q9NIH3

Conserved Domains (1) summary

cd00048
Location:140 → 199

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_001169344.2 → NP_001162815.1 DISCO interacting protein 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162815.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MRC7, Q9NIH3

Conserved Domains (1) summary

cd00048
Location:140 → 199

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A4V4V2		A4V4V2
Q86LT0		Q86LT0
Q8MRC7		Q8MRC7
Q9GNA3		Q9GNA3
Q9GNA6		Q9GNA6
Q9GND0		Q9GND0
Q9GNJ2		Q9GNJ2
Q9NHW9		Q9NHW9
Q9NIH3		Q9NIH3
Q9TW12		Q9TW12
Q9TW27		Q9TW27
Q9U4F5		Q9U4F5
Q9U6N4		Q9U6N4
Q9W5S7		Q9W5S7