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    Prosbeta6 Proteasome beta6 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39855, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prosbeta6provided by FlyBase
    Official Full Name
    Proteasome beta6 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002284
    Locus tag
    Dmel_CG4097
    See related
    AllianceGenome:FB:FBgn0002284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    b6; beta-6; Beta-6; beta6; beta6_dm; CG4097; Dmel\CG4097; DTS-5; DTS5; l(3)73Ai; l(3)DTS-5; l(3)DTS5; pros26; Pros26; Pros26-DTS; pros26B; pros26beta6; prosbeta6; PSB1_DROME; PSMB1
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Used to study neurodegenerative disease. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta6 in Genome Data Viewer
    Location:
    73B1-73B1; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16609400..16610418, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16602500..16603518, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Apollo Neighboring gene pseudo Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45865 Neighboring gene Suppressor of ref(2)P sterility Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis. Velentzas PD, et al. Cell Biol Int, 2011 Jan. PMID 20819072
    2. Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology. Seigle JL, et al. Genetics, 2008 Jun. PMID 18458110, Free PMC Article
    3. Targeted expression of dominant negative proteasome mutants in Drosophila melanogaster. Belote JM, et al. Genesis, 2002 Sep-Oct. PMID 12324954
    4. Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Chan HY, et al. Hum Mol Genet, 2002 Nov 1. PMID 12393801
    5. The Binding of CSL Proteins to Either Co-Activators or Co-Repressors Protects from Proteasomal Degradation Induced by MAPK-Dependent Phosphorylation. Fechner J, et al. Int J Mol Sci, 2022 Oct 15. PMID 36293193, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. assembly of the Drosophila 26 S proteasome accompanied by extensive subunit rearrangements
      Title: Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta6 subunit
    Names
    20S proteasome
    CG4097-PA
    Prosbeta6-PA
    beta6
    beta6 proteosome subunit
    proteasome 26kD subunit
    proteasome beta6
    proteasome subunit 20S

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16609400..16610418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079391.3 → NP_524115.1  proteasome beta6 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40304, Q9VV84
      Related
      FBpp0075119
      Conserved Domains (2) summary
      COG0638
      Location:24 → 225
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03757
      Location:22 → 235
      proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77288 O77288
    P40304.2 P40304

    Gene LinkOut

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