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    FGF4 fibroblast growth factor 4 [ Homo sapiens (human) ]

    Gene ID: 2249, updated on 9-Dec-2024

    Summary

    Official Symbol
    FGF4provided by HGNC
    Official Full Name
    fibroblast growth factor 4provided by HGNC
    Primary source
    HGNC:HGNC:3682
    See related
    Ensembl:ENSG00000075388 MIM:164980; AllianceGenome:HGNC:3682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FGF4 in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69771022..69775341, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69787944..69792263, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69585790..69590109, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8818 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69515109-69516061 Neighboring gene FGF19 5' regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69521101-69521730 Neighboring gene MPRA-validated peak1327 silencer Neighboring gene FGF19 upstream enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69555555-69556140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69556141-69556725 Neighboring gene fibroblast growth factor 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565172-69565761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565762-69566352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69579027-69580027 Neighboring gene DNAJB6 pseudogene 5 Neighboring gene FGF4 3' enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69588083-69589008 Neighboring gene FGF4 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596435-69596972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596973-69597508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69603612-69604157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69604158-69604702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605134-69605838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605839-69606541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69612316-69613027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69613028-69613738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69615738-69616268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69631724-69632244 Neighboring gene FGF3 5' regulatory region Neighboring gene uncharacterized LOC107984368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69640403-69641083 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69647091-69647682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69649493-69650298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69651106-69651911 Neighboring gene MPRA-validated peak1329 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69657667-69658333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:69661705-69662302 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69679525-69680082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680083-69680640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680641-69681198 Neighboring gene fibroblast growth factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69693599-69694230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69698210-69698710 Neighboring gene Sharpr-MPRA regulatory region 8845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69705859-69706454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69720311-69720812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69724011-69724512 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69778215-69779191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69789289-69790190 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69794428-69795627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69810871-69811654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69812439-69813222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69823537-69824036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827276-69827998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827999-69828721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69832189-69833006 Neighboring gene anoctamin 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69871617-69872015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69881245-69881784 Neighboring gene long intergenic non-protein coding RNA 2753

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process involved in morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondroblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cranial suture morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mesenchymal cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 4
    Names
    heparin secretory transforming protein 1
    heparin-binding growth factor 4
    human stomach cancer, transforming factor from FGF-related oncogene
    kaposi sarcoma oncogene
    oncogene HST
    transforming protein KS3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002007.4NP_001998.1  fibroblast growth factor 4 precursor

      See identical proteins and their annotated locations for NP_001998.1

      Status: REVIEWED

      Source sequence(s)
      AA974433, AP001888, AW340506, BF510715, CN429959, M17446
      Consensus CDS
      CCDS8194.1
      UniProtKB/Swiss-Prot
      B7U994, P08620
      UniProtKB/TrEMBL
      A0A7U3JW12
      Related
      ENSP00000168712.1, ENST00000168712.3
      Conserved Domains (1) summary
      pfam00167
      Location:82203
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      69771022..69775341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      69787944..69792263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)