Boc BOC cell adhesion associated, oncogene regulated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bocprovided by MGI
Official Full Name: BOC cell adhesion associated, oncogene regulatedprovided by MGI
Primary source: MGI:MGI:2151153
See related: Ensembl:ENSMUSG00000022687 AllianceGenome:MGI:2151153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mFLJ00376; 4732455C11
Summary: Involved in positive regulation of myoblast differentiation. Acts upstream of or within axon guidance and smoothened signaling pathway. Located in growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 42.5), limb E14.5 (RPKM 40.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B4; 16 28.81 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (44305408..44379233, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (44485045..44558870, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Title: Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Title: The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Boc acts as a Shh-dependent endocytic platform gating Ptch1 internalization and Shh signaling in growth-cone turning and axon guidance.
Title: Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance.
Findings provide evidence for a dual requirement for Boc and Gas1 during early development of the palate, mediating cell cycle regulation during growth and subsequent fusion of the palatal shelves.
Title: Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis.
BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Title: A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc
Title: Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc.
Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma.
Title: The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.
The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent of the retina is required to sustain Zic2 expression, likely by regulating the levels of Shh signaling from the nearby cRGCs. Zic2.
Title: Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.
Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly.
Title: Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.
Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation.
Title: Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Boc (e-PCR), detects polymorphism
- UniSTS:534413

Boc (e-PCR), detects polymorphism
- UniSTS:534414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: brother of CDO

Names: biregional Cdon binding protein; biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172506.2 → NP_766094.1 brother of CDO precursor

See identical proteins and their annotated locations for NP_766094.1

Status: PROVISIONAL

Source sequence(s)

AK028889

Consensus CDS

CCDS28186.1

UniProtKB/Swiss-Prot

Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7

UniProtKB/TrEMBL

D3Z763

Related

ENSMUSP00000110281.3, ENSMUST00000114634.3

Conserved Domains (7) summary

smart00408
Location:332 → 393

IGc2; Immunoglobulin C-2 Type

smart00060
Location:481 → 553

FN3; Fibronectin type 3 domain

smart00410
Location:132 → 207

IG_like; Immunoglobulin like

cd00063
Location:601 → 692

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:318 → 401

I-set; Immunoglobulin I-set domain

pfam16625
Location:404 → 468

ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO

cl11960
Location:243 → 301

Ig; Immunoglobulin domain