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    Foxf1 forkhead box F1 [ Mus musculus (house mouse) ]

    Gene ID: 15227, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxf1provided by MGI
    Official Full Name
    forkhead box F1provided by MGI
    Primary source
    MGI:MGI:1347470
    See related
    Ensembl:ENSMUSG00000042812 AllianceGenome:MGI:1347470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hfh8; HFH-8; FREAC1; Foxf1a; Freac-1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesenchyme morphogenesis; regulation of transcription by RNA polymerase II; and respiratory system development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 158.2), colon adult (RPKM 48.1) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Foxf1 in Genome Data Viewer
    Location:
    8 E1; 8 70.31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121811100..121814883)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121084386..121088154)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46071 Neighboring gene Foxf1 adjacent non-coding developmental regulatory RNA Neighboring gene methenyltetrahydrofolate synthetase domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123632389-123632572 Neighboring gene STARR-positive B cell enhancer ABC_E9747 Neighboring gene forkhead box C2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac left ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ductus arteriosus closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ductus arteriosus closure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic digestive tract development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic ectodermal digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic ectodermal digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocardial cushion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation involved in mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lateral mesodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung lobe morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesenchyme migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midgut development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midgut development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in morphogenesis of a branching structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in respiratory tube development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within right lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within trachea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in trachea development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ureter development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ureter development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in venous blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in venous blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    forkhead box protein F1
    Names
    HNF-3/forkhead homolog 8
    forkhead box F1a
    forkhead-related protein FKHL5
    forkhead-related transcription factor 1
    hepatocyte nuclear factor 3 forkhead homolog 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010426.3NP_034556.2  forkhead box protein F1

      See identical proteins and their annotated locations for NP_034556.2

      Status: VALIDATED

      Source sequence(s)
      AC124170
      Consensus CDS
      CCDS22722.2
      UniProtKB/Swiss-Prot
      B2RSC1, Q61080, Q61661
      Related
      ENSMUSP00000137662.2, ENSMUST00000181504.2
      Conserved Domains (1) summary
      pfam00250
      Location:48133
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      121811100..121814883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)