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    Lamp1 lysosomal-associated membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16783, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lamp1provided by MGI
    Official Full Name
    lysosomal-associated membrane protein 1provided by MGI
    Primary source
    MGI:MGI:96745
    See related
    Ensembl:ENSMUSG00000031447 AllianceGenome:MGI:96745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2B; Perk; LGP-A; CD107a; Lamp-1; LGP-120
    Summary
    Enables protein domain specific binding activity. Involved in protein stabilization. Located in several cellular components, including cytoplasmic vesicle; sarcolemma; and vacuole. Is active in lysosome. Is expressed in several structures, including central nervous system; craniocervical region bone; egg cylinder; oocyte; and sensory organ. Orthologous to human LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 604.1), genital fat pad adult (RPKM 489.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lamp1 in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13209161..13225338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13159161..13175338)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene GH regulated TBC protein 1 Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene microRNA 1968

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of protein localization to organelle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in granzyme-mediated programmed cell death signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosomal lumen acidification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of natural killer cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of organelle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytolytic granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytolytic granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytolytic granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in phagolysosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysosome-associated membrane glycoprotein 1
    Names
    120 kDa lysosomal membrane glycoprotein
    CD107 antigen-like family member A
    LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B)
    Lamp I
    lysosomal membrane glycoprotein 1
    lysosomal membrane glycoprotein A
    lysosome-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317353.1NP_001304282.1  lysosome-associated membrane glycoprotein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI835725, AK004637, BC049097
      UniProtKB/TrEMBL
      Q3TX84, Q8VH34, Q9DC13
      Conserved Domains (2) summary
      cd12087
      Location:372401
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      pfam01299
      Location:107407
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    2. NM_010684.3NP_034814.2  lysosome-associated membrane glycoprotein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034814.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI835725, AK159376, BC049097
      Consensus CDS
      CCDS22106.1
      UniProtKB/Swiss-Prot
      P11438, Q62020
      UniProtKB/TrEMBL
      Q3TA96, Q3TX84, Q8VH34
      Related
      ENSMUSP00000033824.7, ENSMUST00000033824.8
      Conserved Domains (2) summary
      cd12087
      Location:371400
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      pfam01299
      Location:106406
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13209161..13225338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)