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    Fbxl18 F-box and leucine-rich repeat protein 18 [ Mus musculus (house mouse) ]

    Gene ID: 231863, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl18provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 18provided by MGI
    Primary source
    MGI:MGI:2444450
    See related
    Ensembl:ENSMUSG00000066640 AllianceGenome:MGI:2444450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130019G13Rik; C330021B20Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL18 (F-box and leucine rich repeat protein 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 23.9), adrenal adult (RPKM 20.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl18 in Genome Data Viewer
    Location:
    5 G2; 5 81.79 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142852701..142882696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142871789..142896721, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15770 Neighboring gene predicted gene, 52793 Neighboring gene predicted gene, 38733 Neighboring gene STARR-positive B cell enhancer ABC_E6395 Neighboring gene STARR-positive B cell enhancer ABC_E674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143670916-143671255 Neighboring gene actin, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143682513-143682666 Neighboring gene STARR-seq mESC enhancer starr_14775 Neighboring gene STARR-seq mESC enhancer starr_14777 Neighboring gene fascin actin-bundling protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033312.3NP_001028484.2  F-box/LRR-repeat protein 18

      See identical proteins and their annotated locations for NP_001028484.2

      Status: VALIDATED

      Source sequence(s)
      AK049302, AK144757
      Consensus CDS
      CCDS19831.1
      UniProtKB/TrEMBL
      F8VQK6, Q3U4A0
      Related
      ENSMUSP00000041700.8, ENSMUST00000035985.8
      Conserved Domains (2) summary
      sd00034
      Location:522548
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:2264
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142852701..142882696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165103.1XP_036020996.1  F-box/LRR-repeat protein 18 isoform X1

      UniProtKB/TrEMBL
      Q3U4A0
      Conserved Domains (1) summary
      sd00034
      Location:433459
      LRR_AMN1; leucine-rich repeat [structural motif]

    RNA

    1. XR_004942509.1 RNA Sequence