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    Abcb1a ATP-binding cassette, sub-family B member 1A [ Mus musculus (house mouse) ]

    Gene ID: 18671, updated on 27-Nov-2024

    Summary

    Official Symbol
    Abcb1aprovided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 1Aprovided by MGI
    Primary source
    MGI:MGI:97570
    See related
    Ensembl:ENSMUSG00000040584 AllianceGenome:MGI:97570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon adult (RPKM 25.6), large intestine adult (RPKM 9.1) and 15 other tissues See more
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    Genomic context

    See Abcb1a in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8617091..8798575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8567091..8748575)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene DBF4 zinc finger Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene STARR-seq mESC enhancer starr_12393 Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene STARR-seq mESC enhancer starr_12396 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene STARR-seq mESC enhancer starr_12398 Neighboring gene calponin 3, acidic pseudogene Neighboring gene ATP-binding cassette, sub-family B member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase-coupled transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide floppase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ceramide floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine floppase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine floppase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine flippase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carboxylic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hyperosmotic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to borneol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to external biotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mycotoxin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nonylphenol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ceramide translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ceramide translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ceramide translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in daunorubicin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of blood-retinal barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal absorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of Sertoli cell barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intestinal absorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alcohol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to antineoplastic agent IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to codeine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cyclosporin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucagon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glycoside IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to quercetin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to thyroxine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in terpenoid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ATP-dependent translocase ABCB1
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 1A
    ATP-binding cassette, sub-family B (MDR/TAP), member 4
    ATP-binding cassette, subfamily B, member 1A
    P-glycoprotein 3
    ecotropic viral integration site 32
    multi-drug resistance 3
    multidrug resistance protein 3
    multiple drug resistant 1a
    phospholipid transporter ABCB1
    NP_035206.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011076.3NP_035206.2  ATP-dependent translocase ABCB1

      See identical proteins and their annotated locations for NP_035206.2

      Status: VALIDATED

      Source sequence(s)
      AC107733, AC121955, AC140398
      Consensus CDS
      CCDS19084.1
      UniProtKB/Swiss-Prot
      P21447, Q5I1Y5
      Related
      ENSMUSP00000041204.5, ENSMUST00000047753.5
      Conserved Domains (1) summary
      PTZ00265
      Location:471263
      PTZ00265; multidrug resistance protein (mdr1); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8617091..8798575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)