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    Klhl21 kelch-like 21 [ Mus musculus (house mouse) ]

    Gene ID: 242785, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhl21provided by MGI
    Official Full Name
    kelch-like 21provided by MGI
    Primary source
    MGI:MGI:1919288
    See related
    Ensembl:ENSMUSG00000073700 AllianceGenome:MGI:1919288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0469; D330008A20; 1810045K06Rik
    Summary
    Predicted to enable cullin family protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including chromosome passenger complex localization to spindle midzone; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in polar microtubule. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human KLHL21 (kelch like family member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 40.0), adrenal adult (RPKM 35.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Klhl21 in Genome Data Viewer
    Location:
    4 E2; 4 82.82 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152093348..152102134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152008891..152017677)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene THAP domain containing, apoptosis associated protein 3 Neighboring gene PHD finger protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E6290 Neighboring gene STARR-positive B cell enhancer ABC_E3557 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene STARR-positive B cell enhancer ABC_E6291 Neighboring gene STARR-seq mESC enhancer starr_12192 Neighboring gene taste receptor, type 1, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome passenger complex localization to spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome passenger complex localization to spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in polar microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033352.3NP_001028524.1  kelch-like protein 21

      See identical proteins and their annotated locations for NP_001028524.1

      Status: PROVISIONAL

      Source sequence(s)
      AL611927
      Consensus CDS
      CCDS18983.1
      UniProtKB/Swiss-Prot
      B1AS70, Q3TZ30, Q3U410
      Related
      ENSMUSP00000095380.4, ENSMUST00000097773.4
      Conserved Domains (2) summary
      sd00038
      Location:326368
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:49547
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152093348..152102134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)