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    Nup188 nucleoporin 188 [ Mus musculus (house mouse) ]

    Gene ID: 227699, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nup188provided by MGI
    Official Full Name
    nucleoporin 188provided by MGI
    Primary source
    MGI:MGI:2446190
    See related
    Ensembl:ENSMUSG00000052533 AllianceGenome:MGI:2446190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in Sandestig-Stefanova syndrome and respiratory failure. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.6), thymus adult (RPKM 23.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nup188 in Genome Data Viewer
    Location:
    2 B; 2 21.49 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30176419..30234278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30286407..30344266)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0169

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nucleoporin NUP188
    Names
    nucleoporin NUP188 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410239.1NP_001397168.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
    2. NM_001410240.1NP_001397169.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
    3. NM_001410241.1NP_001397170.1  nucleoporin NUP188 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954388
    4. NM_001410242.1NP_001397171.1  nucleoporin NUP188 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      A2AWI5
      Related
      ENSMUSP00000109264.3, ENSMUST00000113634.3
    5. NM_001410243.1NP_001397172.1  nucleoporin NUP188 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      F2Z4A7, J3JSA4
      Related
      ENSMUSP00000122398.2, ENSMUST00000138666.8
    6. NM_198304.4NP_938046.2  nucleoporin NUP188 isoform 1

      See identical proteins and their annotated locations for NP_938046.2

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15878.1
      UniProtKB/Swiss-Prot
      Q4VA15, Q6ZQH8, Q80UL4, Q8C7A1, Q8R3F1
      Related
      ENSMUSP00000065836.6, ENSMUST00000064447.12
      Conserved Domains (1) summary
      pfam10487
      Location:31941
      Nup188; Nucleoporin subcomplex protein binding to Pom34

    RNA

    1. NR_156132.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954388

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30176419..30234278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249849.1XP_030105709.1  nucleoporin NUP188 isoform X1

      Conserved Domains (1) summary
      pfam10487
      Location:4828
      Nup188; Nucleoporin subcomplex protein binding to Pom34