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    Prkcq protein kinase C, theta [ Mus musculus (house mouse) ]

    Gene ID: 18761, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prkcqprovided by MGI
    Official Full Name
    protein kinase C, thetaprovided by MGI
    Primary source
    MGI:MGI:97601
    See related
    Ensembl:ENSMUSG00000026778 AllianceGenome:MGI:97601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkcq; PKC-0; PKCtheta; PKC-theta; A130035A12Rik
    Summary
    Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including positive regulation of T-helper 17 type immune response; regulation of cell-cell adhesion; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-2 production; and protein phosphorylation. Located in cytoplasm and immunological synapse. Is expressed in several structures, including adipose tissue; genitourinary system; gut; limb; and nervous system. Used to study retinal detachment. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 34.4), thymus adult (RPKM 13.0) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prkcq in Genome Data Viewer
    Location:
    2 A1; 2 8.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11176922..11306033)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11171905..11301226)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03659 Neighboring gene STARR-seq mESC enhancer starr_03660 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene zinc finger and BTB domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03661 Neighboring gene STARR-positive B cell enhancer ABC_E2601 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11116705-11116814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11126023-11126241 Neighboring gene STARR-seq mESC enhancer starr_03662 Neighboring gene STARR-seq mESC enhancer starr_03663 Neighboring gene STARR-positive B cell enhancer mm9_chr2:11210120-11210420 Neighboring gene STARR-positive B cell enhancer ABC_E10081 Neighboring gene RIKEN cDNA 8030442B05 gene Neighboring gene predicted gene, 38171 Neighboring gene predicted gene 13293

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol-dependent serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 2 cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C theta type
    Names
    PKC theta
    nPKC-theta
    NP_001405286.1
    NP_001405287.1
    NP_001405288.1
    NP_032885.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418357.1NP_001405286.1  protein kinase C theta type isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928715, AL929020
      UniProtKB/TrEMBL
      F8WGT6
    2. NM_001418358.1NP_001405287.1  protein kinase C theta type isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL928715, AL929020
      UniProtKB/TrEMBL
      F8WGT6
    3. NM_001418359.1NP_001405288.1  protein kinase C theta type isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL929020
      UniProtKB/TrEMBL
      Q920N8
      Related
      ENSMUST00000195628.2
    4. NM_008859.3NP_032885.1  protein kinase C theta type isoform 1

      See identical proteins and their annotated locations for NP_032885.1

      Status: VALIDATED

      Source sequence(s)
      AL928715, AL929020
      Consensus CDS
      CCDS15682.1
      UniProtKB/Swiss-Prot
      Q02111
      UniProtKB/TrEMBL
      A6H667, F8WGT6
      Related
      ENSMUSP00000028118.4, ENSMUST00000028118.9
      Conserved Domains (3) summary
      smart00220
      Location:380634
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05619
      Location:374704
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
      pfam00130
      Location:232284
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11176922..11306033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178075.2: Suppressed sequence

      Description
      NM_178075.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.