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    Sftpa1 surfactant associated protein A1 [ Mus musculus (house mouse) ]

    Gene ID: 20387, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sftpa1provided by MGI
    Official Full Name
    surfactant associated protein A1provided by MGI
    Primary source
    MGI:MGI:109518
    See related
    Ensembl:ENSMUSG00000021789 AllianceGenome:MGI:109518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP-A; Sftp1; Sftp-1
    Summary
    Predicted to enable carbohydrate binding activity and metal ion binding activity. Predicted to be involved in positive regulation of phagocytosis. Located in collagen-containing extracellular matrix. Is expressed in extraembryonic component; lung; lung surfactant; and placenta. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to human SFTPA1 (surfactant protein A1) and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward lung adult (RPKM 365.5) See more
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    Genomic context

    See Sftpa1 in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40853745..40858330)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (41131788..41136373)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DPY30 domain containing 2 Neighboring gene DPY30 domain containing 1 Neighboring gene methionine adenosyltransferase 1A Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 2 pseudogene Neighboring gene mannose-binding lectin (protein A) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pulmonary surfactant-associated protein A
    Names
    PSAP
    PSP-A
    surfactant pulmonary associated protein A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023134.5NP_075623.2  pulmonary surfactant-associated protein A precursor

      See identical proteins and their annotated locations for NP_075623.2

      Status: VALIDATED

      Source sequence(s)
      AC124400
      Consensus CDS
      CCDS26960.1
      UniProtKB/Swiss-Prot
      P35242
      UniProtKB/TrEMBL
      Q9CQI1
      Related
      ENSMUSP00000129696.2, ENSMUST00000170719.2
      Conserved Domains (2) summary
      cd03591
      Location:136248
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:2798
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40853745..40858330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)