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    Slc19a1 solute carrier family 19 (folate transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20509, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc19a1provided by MGI
    Official Full Name
    solute carrier family 19 (folate transporter), member 1provided by MGI
    Primary source
    MGI:MGI:103182
    See related
    Ensembl:ENSMUSG00000001436 AllianceGenome:MGI:103182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RFC; RFC1; RFC-1
    Summary
    Enables folic acid transmembrane transporter activity and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and methotrexate transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 62.7), ovary adult (RPKM 25.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc19a1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76868103..76886266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77032269..77050432)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35721 Neighboring gene STARR-seq mESC enhancer starr_27188 Neighboring gene predicted gene 10787 Neighboring gene predicted gene, 3137 Neighboring gene collagen, type XVIII, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_27190 Neighboring gene spermidine synthase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27194 Neighboring gene STARR-seq mESC enhancer starr_27197 Neighboring gene STARR-seq mESC enhancer starr_27199 Neighboring gene predicted gene, 35837 Neighboring gene predicted gene, 40704

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2',3'-cyclic GMP-AMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 2',3'-cyclic GMP-AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables cyclic-GMP-AMP transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclic-GMP-AMP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables folate:monoatomic anion antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables folate:monoatomic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables folate:monoatomic anion antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables folic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables folic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methotrexate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methotrexate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NOT involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in folate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in folate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in folate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in folate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in folate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in folic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methotrexate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in methotrexate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    reduced folate transporter
    Names
    IFC-1
    folate transporter 1
    intestinal folate carrier 1
    intestinal folate carrier protein
    plasma membrane folate antiporter SLC19A1
    reduced folate carrier 1
    solute carrier family 19 (sodium/hydrogen exchanger), member 1
    solute carrier family 19 member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199271.2NP_001186200.1  reduced folate transporter isoform a

      See identical proteins and their annotated locations for NP_001186200.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon for its 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC055777
      Consensus CDS
      CCDS35947.1
      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
      Related
      ENSMUSP00000116784.2, ENSMUST00000144234.8
      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier
    2. NM_001428820.1NP_001415749.1  reduced folate transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC055777
      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
    3. NM_001428821.1NP_001415750.1  reduced folate transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC055777
      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
    4. NM_001428822.1NP_001415751.1  reduced folate transporter isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform b.
      Source sequence(s)
      AC055777
    5. NM_001428823.1NP_001415752.1  reduced folate transporter isoform b

      Status: VALIDATED

      Source sequence(s)
      AC055777
    6. NM_001428824.1NP_001415753.1  reduced folate transporter isoform c

      Status: VALIDATED

      Source sequence(s)
      AC055777
    7. NM_001428825.1NP_001415754.1  reduced folate transporter isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform d.
      Source sequence(s)
      AC055777
    8. NM_001428826.1NP_001415755.1  reduced folate transporter isoform d

      Status: VALIDATED

      Source sequence(s)
      AC055777
    9. NM_001428827.1NP_001415756.1  reduced folate transporter isoform e

      Status: VALIDATED

      Source sequence(s)
      AC055777
    10. NM_001428828.1NP_001415757.1  reduced folate transporter isoform f

      Status: VALIDATED

      Source sequence(s)
      AC055777
    11. NM_031196.4NP_112473.1  reduced folate transporter isoform a

      See identical proteins and their annotated locations for NP_112473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC055777
      Consensus CDS
      CCDS35947.1
      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
      Related
      ENSMUSP00000101050.4, ENSMUST00000105410.10
      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier

    RNA

    1. NR_190499.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    2. NR_190500.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    3. NR_190501.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    4. NR_190502.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    5. NR_190503.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    6. NR_190504.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    7. NR_190505.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    8. NR_190506.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    9. NR_190507.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    10. NR_190508.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    11. NR_190509.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777
    12. NR_190510.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055777

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76868103..76886266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513416.4XP_006513479.1  reduced folate transporter isoform X1

      See identical proteins and their annotated locations for XP_006513479.1

      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier
    2. XM_006513417.4XP_006513480.1  reduced folate transporter isoform X1

      See identical proteins and their annotated locations for XP_006513480.1

      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier
    3. XM_030244971.2XP_030100831.1  reduced folate transporter isoform X2

      Conserved Domains (1) summary
      cl27502
      Location:1273
      Folate_carrier; Reduced folate carrier
    4. XM_006513414.5XP_006513477.1  reduced folate transporter isoform X1

      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier
    5. XM_006513419.5XP_006513482.1  reduced folate transporter isoform X2

      Conserved Domains (1) summary
      cl27502
      Location:1273
      Folate_carrier; Reduced folate carrier
    6. XM_036155714.1XP_036011607.1  reduced folate transporter isoform X3

      Conserved Domains (1) summary
      cl27502
      Location:1273
      Folate_carrier; Reduced folate carrier
    7. XM_006513415.5XP_006513478.1  reduced folate transporter isoform X1

      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier
    8. XM_036155713.1XP_036011606.1  reduced folate transporter isoform X1

      UniProtKB/Swiss-Prot
      P41438, Q62450, Q62451
      UniProtKB/TrEMBL
      Q542F3, Q9DCR3
      Conserved Domains (1) summary
      TIGR00806
      Location:1512
      rfc; RFC reduced folate carrier

    RNA

    1. XR_003948633.2 RNA Sequence

    2. XR_004936130.1 RNA Sequence

    3. XR_004936132.1 RNA Sequence

    4. XR_003948634.2 RNA Sequence

    5. XR_004936133.1 RNA Sequence

    6. XR_004936131.1 RNA Sequence

    7. XR_003948632.2 RNA Sequence

    8. XR_003948631.2 RNA Sequence