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    Olig3 oligodendrocyte transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 94222, updated on 27-Nov-2024

    Summary

    Official Symbol
    Olig3provided by MGI
    Official Full Name
    oligodendrocyte transcription factor 3provided by MGI
    Primary source
    MGI:MGI:2149955
    See related
    Ensembl:ENSMUSG00000045591 AllianceGenome:MGI:2149955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bhlhb7; oligo3; bHLHe20
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; inner ear; and skeletal muscle. Orthologous to human OLIG3 (oligodendrocyte transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Olig3 in Genome Data Viewer
    Location:
    10 A3; 10 8.33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19232287..19234352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19356539..19358604)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene enolase 2, gamma neuronal pseudogene Neighboring gene predicted gene, 33056 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19053290-19053443 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19093659-19093906 Neighboring gene STARR-seq mESC enhancer starr_25934 Neighboring gene STARR-seq mESC enhancer starr_25935 Neighboring gene STARR-seq mESC enhancer starr_25937 Neighboring gene predicted gene, 33104 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19238623-19238923 Neighboring gene STARR-seq mESC enhancer starr_25938 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19303894-19304196 Neighboring gene STARR-positive B cell enhancer ABC_E2317 Neighboring gene interferon gamma receptor 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    oligodendrocyte transcription factor 3
    Names
    basic helix-loop-helix domain-containing class B protein 7
    oligodendrocyte-specific bHLH transcription factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053008.3NP_443734.2  oligodendrocyte transcription factor 3

      See identical proteins and their annotated locations for NP_443734.2

      Status: VALIDATED

      Source sequence(s)
      AC159708
      Consensus CDS
      CCDS35855.1
      UniProtKB/Swiss-Prot
      Q6PFG8, Q9EQW5
      Related
      ENSMUSP00000057106.6, ENSMUST00000053225.7
      Conserved Domains (1) summary
      pfam00010
      Location:86139
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      19232287..19234352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)