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    Aim2 absent in melanoma 2 [ Mus musculus (house mouse) ]

    Gene ID: 383619, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aim2provided by MGI
    Official Full Name
    absent in melanoma 2provided by MGI
    Primary source
    MGI:MGI:2686159
    See related
    Ensembl:ENSMUSG00000037860 AllianceGenome:MGI:2686159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1313; Ifi210
    Summary
    Enables several functions, including identical protein binding activity; pattern recognition receptor activity; and signaling adaptor activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of macromolecule metabolic process; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Part of AIM2 inflammasome complex. Is active in cytoplasm; nucleus; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 1.0), CNS E11.5 (RPKM 0.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Aim2 in Genome Data Viewer
    Location:
    1 H3; 1 80.33 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173177105..173293606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173349547..173466040)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mucosal pentraxin 2 Neighboring gene STARR-seq mESC enhancer starr_03074 Neighboring gene STARR-seq mESC enhancer starr_03075 Neighboring gene atypical chemokine receptor 1 (Duffy blood group) Neighboring gene cell adhesion molecule 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175328755-175329056 Neighboring gene STARR-seq mESC enhancer starr_03076 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT) Neighboring gene STARR-positive B cell enhancer ABC_E2021 Neighboring gene STARR-seq mESC enhancer starr_03077 Neighboring gene STARR-positive B cell enhancer ABC_E1574 Neighboring gene STARR-seq mESC enhancer starr_03078 Neighboring gene STARR-positive B cell enhancer ABC_E5856 Neighboring gene STARR-positive B cell enhancer ABC_E11107 Neighboring gene STARR-seq mESC enhancer starr_03079 Neighboring gene interferon activated gene 206 Neighboring gene STARR-seq mESC enhancer starr_03080 Neighboring gene STARR-positive B cell enhancer ABC_E10059 Neighboring gene STARR-positive B cell enhancer ABC_E4392 Neighboring gene interferon activated gene 214

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in AIM2 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in defense response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron cellular homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pattern recognition receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptosome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyroptotic inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of AIM2 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AIM2 inflammasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AIM2 inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-inducible protein AIM2
    Names
    ifi-210
    interferon-inducible protein 210
    interferon-inducible protein p210

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013779.2NP_001013801.2  interferon-inducible protein AIM2

      See identical proteins and their annotated locations for NP_001013801.2

      Status: VALIDATED

      Source sequence(s)
      AC084073, AK050724, DT921984
      Consensus CDS
      CCDS15529.2
      UniProtKB/Swiss-Prot
      Q91VJ1
      Related
      ENSMUSP00000132253.3, ENSMUST00000166137.3
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173177105..173293606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166274.1XP_036022167.1  interferon-inducible protein AIM2 isoform X3

      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156276
      HIN; HIN-200/IF120x domain
    2. XM_036166269.1XP_036022162.1  interferon-inducible protein AIM2 isoform X3

      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156276
      HIN; HIN-200/IF120x domain
    3. XM_036166268.1XP_036022161.1  interferon-inducible protein AIM2 isoform X2

      Conserved Domains (2) summary
      cd08305
      Location:1058
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:125290
      HIN; HIN-200/IF120x domain
    4. XM_036166266.1XP_036022159.1  interferon-inducible protein AIM2 isoform X2

      Conserved Domains (2) summary
      cd08305
      Location:1058
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:125290
      HIN; HIN-200/IF120x domain
    5. XM_036166267.1XP_036022160.1  interferon-inducible protein AIM2 isoform X2

      Conserved Domains (2) summary
      cd08305
      Location:1058
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:125290
      HIN; HIN-200/IF120x domain
    6. XM_036166259.1XP_036022152.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    7. XM_036166264.1XP_036022157.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    8. XM_036166265.1XP_036022158.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    9. XM_006496926.3XP_006496989.1  interferon-inducible protein AIM2 isoform X1

      See identical proteins and their annotated locations for XP_006496989.1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    10. XM_030255241.2XP_030111101.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    11. XM_036166247.1XP_036022140.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    12. XM_036166244.1XP_036022137.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    13. XM_036166245.1XP_036022138.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    14. XM_036166238.1XP_036022131.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    15. XM_036166249.1XP_036022142.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Related
      ENSMUSP00000119465.2, ENSMUST00000147604.8
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    16. XM_017321496.3XP_017176985.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    17. XM_017321486.3XP_017176975.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    18. XM_017321501.3XP_017176990.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    19. XM_017321492.3XP_017176981.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    20. XM_017321498.3XP_017176987.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    21. XM_011238835.3XP_011237137.1  interferon-inducible protein AIM2 isoform X1

      See identical proteins and their annotated locations for XP_011237137.1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    22. XM_011238842.3XP_011237144.1  interferon-inducible protein AIM2 isoform X1

      See identical proteins and their annotated locations for XP_011237144.1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    23. XM_006496919.4XP_006496982.1  interferon-inducible protein AIM2 isoform X1

      See identical proteins and their annotated locations for XP_006496982.1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    24. XM_036166246.1XP_036022139.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    25. XM_036166248.1XP_036022141.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    26. XM_011238831.4XP_011237133.1  interferon-inducible protein AIM2 isoform X1

      See identical proteins and their annotated locations for XP_011237133.1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    27. XM_036166260.1XP_036022153.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    28. XM_036166262.1XP_036022155.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    29. XM_017321505.3XP_017176994.1  interferon-inducible protein AIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ1
      Conserved Domains (2) summary
      cd08305
      Location:1079
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:156321
      HIN; HIN-200/IF120x domain
    30. XM_030255292.2XP_030111152.1  interferon-inducible protein AIM2 isoform X2

      Conserved Domains (2) summary
      cd08305
      Location:1058
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:125290
      HIN; HIN-200/IF120x domain
    31. XM_006496929.3XP_006496992.1  interferon-inducible protein AIM2 isoform X4

      Conserved Domains (1) summary
      pfam02760
      Location:13178
      HIN; HIN-200/IF120x domain