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    MCTP2 multiple C2 and transmembrane domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 55784, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MCTP2provided by HGNC
    Official Full Name
    multiple C2 and transmembrane domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25636
    See related
    Ensembl:ENSG00000140563 MIM:616297; AllianceGenome:HGNC:25636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Located in cytosol; membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 5.6), placenta (RPKM 4.8) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MCTP2 in Genome Data Viewer
    Location:
    15q26.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (94231366..94483952)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (91994258..92247994)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (94774790..95027181)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370984 Neighboring gene H3 histone pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6851 Neighboring gene ribosomal protein L26 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10135 Neighboring gene long intergenic non-protein coding RNA 2852 Neighboring gene uncharacterized LOC105370986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE). Djurovic S, et al. Psychiatry Res, 2009 Aug 15. PMID 19223264
    2. MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development. Lalani SR, et al. Hum Mol Genet, 2013 Nov 1. PMID 23773997, Free PMC Article
    3. Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia). Sun Y, et al. Genetics, 2024 Jun 5. PMID 38547502
    4. Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains. Joshi AS, et al. Mol Biol Cell, 2021 Jun 1. PMID 33826368, Free PMC Article
    5. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis. Liu Y, et al. J Egypt Natl Canc Inst, 2024 Mar 18. PMID 38494582

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia).
      Title: Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia).
    2. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
      Title: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
    3. Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
      Title: Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
    4. Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
      Title: Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
    5. Results identify MCTP2 as a novel genetic cause of coarctation of the aorta and related cardiac malformations.
      Title: MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. The present study suggested that MCPT2 gene as aputative susceptibility gene for schizophrenia of Scandinavian origin.
      Title: Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE).
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE).
    9. MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules
      Title: Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and performance on standardized cognitive tests.
    EBI GWAS Catalog
    Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
    EBI GWAS Catalog
    Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
    EBI GWAS Catalog
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
    EBI GWAS Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog
    HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
    EBI GWAS Catalog
    New susceptibility loci associated with kidney disease in type 1 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11175, FLJ33303, MGC111402

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multiple C2 and transmembrane domain-containing protein 2
    Names
    multiple C2 domains, transmembrane 2
    multiple C2-domains with two transmembrane regions 2 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159643.2 → NP_001153115.1  multiple C2 and transmembrane domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001153115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is lacking two consecutive in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS53975.1
      UniProtKB/Swiss-Prot
      Q6DN12
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:716 → 769
      PRT_C; Plant phosphoribosyltransferase C-terminal

    2. NM_001159644.2 → NP_001153116.1  multiple C2 and transmembrane domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001153116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate segment at the 5' end, and an alternate exon at the 3' end (causing a frame-shift) compared to variant 1. This results in translation initiation from a downstream start codon and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC103749, BC025708, DA862691
      Consensus CDS
      CCDS53976.1
      UniProtKB/Swiss-Prot
      Q6DN12
      Related
      ENSP00000454847.1, ENST00000557742.1
      Conserved Domains (2) summary
      cd08377
      Location:97 → 215
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cl14603
      Location:1 → 57
      C2; C2 domain

    3. NM_001385001.1 → NP_001371930.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 5, and 6, encodes isoform 1.
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS32338.1
      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Related
      ENSP00000350377.4, ENST00000357742.10
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    4. NM_001385002.1 → NP_001371931.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, and 6, encodes isoform 1.
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS32338.1
      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    5. NM_001385003.1 → NP_001371932.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, and 5, encodes isoform 1.
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS32338.1
      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    6. NM_001385004.1 → NP_001371933.1  multiple C2 and transmembrane domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS53975.1
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:716 → 769
      PRT_C; Plant phosphoribosyltransferase C-terminal

    7. NM_001385005.1 → NP_001371934.1  multiple C2 and transmembrane domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:757 → 810
      PRT_C; Plant phosphoribosyltransferase C-terminal

    8. NM_001385006.1 → NP_001371935.1  multiple C2 and transmembrane domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:730 → 783
      PRT_C; Plant phosphoribosyltransferase C-terminal

    9. NM_001385007.1 → NP_001371936.1  multiple C2 and transmembrane domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (4) summary
      cd04042
      Location:101 → 220
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:263 → 375
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:415 → 533
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:677 → 730
      PRT_C; Plant phosphoribosyltransferase C-terminal

    10. NM_001385008.1 → NP_001371937.1  multiple C2 and transmembrane domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (3) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

    11. NM_001385009.1 → NP_001371938.1  multiple C2 and transmembrane domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (4) summary
      cd04042
      Location:29 → 148
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:191 → 303
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:343 → 461
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:605 → 658
      PRT_C; Plant phosphoribosyltransferase C-terminal

    12. NM_001385010.1 → NP_001371939.1  multiple C2 and transmembrane domain-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (4) summary
      cd04042
      Location:29 → 148
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:191 → 303
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:343 → 461
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:550 → 603
      PRT_C; Plant phosphoribosyltransferase C-terminal

    13. NM_001385011.1 → NP_001371940.1  multiple C2 and transmembrane domain-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626
      Conserved Domains (3) summary
      cd04042
      Location:101 → 220
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:251 → 363
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:403 → 521
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

    14. NM_018349.4 → NP_060819.3  multiple C2 and transmembrane domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_060819.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AC103749, AC110027, AC135626
      Consensus CDS
      CCDS32338.1
      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    RNA

    1. NR_169526.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    2. NR_169527.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    3. NR_169528.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    4. NR_169529.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    5. NR_169530.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    6. NR_169531.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    7. NR_169532.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103749, AC110027, AC135626

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      94231366..94483952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432839.1 → XP_047288795.1  multiple C2 and transmembrane domain-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    2. XM_047432840.1 → XP_047288796.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

      Related
      ENSP00000395109.3, ENST00000451018.7

    3. XM_011521774.3 → XP_011520076.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

    4. XM_047432842.1 → XP_047288798.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    5. XM_047432843.1 → XP_047288799.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

    6. XM_047432841.1 → XP_047288797.1  multiple C2 and transmembrane domain-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    7. XM_005254960.2 → XP_005255017.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

      See identical proteins and their annotated locations for XP_005255017.1

      UniProtKB/Swiss-Prot
      Q6DN12
      Conserved Domains (3) summary
      cd08377
      Location:97 → 215
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:359 → 412
      PRT_C; Plant phosphoribosyltransferase C-terminal
      cl14603
      Location:1 → 57
      C2; C2 domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      91994258..92247994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378418.1 → XP_054234393.1  multiple C2 and transmembrane domain-containing protein 2 isoform X6

    2. XM_054378423.1 → XP_054234398.1  multiple C2 and transmembrane domain-containing protein 2 isoform X7

    3. XM_054378420.1 → XP_054234395.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    4. XM_054378419.1 → XP_054234394.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

    5. XM_054378421.1 → XP_054234396.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    6. XM_054378422.1 → XP_054234397.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

    7. XM_054378424.1 → XP_054234399.1  multiple C2 and transmembrane domain-containing protein 2 isoform X8

    8. XM_054378425.1 → XP_054234400.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DN12.3 GenPept UniProtKB/Swiss-Prot:Q6DN12

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