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    GOLGA4 golgin A4 [ Homo sapiens (human) ]

    Gene ID: 2803, updated on 10-Dec-2024

    Summary

    Official Symbol
    GOLGA4provided by HGNC
    Official Full Name
    golgin A4provided by HGNC
    Primary source
    HGNC:HGNC:4427
    See related
    Ensembl:ENSG00000144674 MIM:602509; AllianceGenome:HGNC:4427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP2; GOLG; p230; CRPF46; MU-RMS-40.18
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GOLGA4 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37243271..37366879)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37244671..37368411)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37284762..37408370)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377642 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124909483 Neighboring gene CRISPRi-validated cis-regulatory element chr3.1280 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:37283961-37284580 and GRCh37_chr3:37284581-37285200 Neighboring gene GOLGA4 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:37339657-37340856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:37343371-37344032 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene MPRA-validated peak4611 silencer Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37485219-37485403 Neighboring gene APRG1 tumor suppressor candidate Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516063-37516575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516576-37517087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37539704-37540204 Neighboring gene integrin subunit alpha 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37579429-37579930 Neighboring gene RNA, U7 small nuclear 73 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with the ER marker Erp57 and the Golgi marker p230 at subcellular perinuclear compartments in neuronal cells PubMed
    Nef nef Genome-wide shRNA screening identifies GOLGA4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    Vpu vpu HIV-1 Vpu co-localizes with the TGN marker p230 (Golgin) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    golgin subfamily A member 4
    Names
    256 kDa golgin
    72.1 protein
    centrosome-related protein F46
    golgi autoantigen, golgin subfamily a, 4
    golgin-240
    golgin-245
    protein 72.1
    trans-Golgi p230

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047053.1 RefSeqGene

      Range
      5081..128689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172713.3NP_001166184.1  golgin subfamily A member 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC097359
      Consensus CDS
      CCDS54564.1
      UniProtKB/Swiss-Prot
      Q13439
      UniProtKB/TrEMBL
      Q49A56
      Related
      ENSP00000349305.4, ENST00000356847.8
      Conserved Domains (2) summary
      smart00755
      Location:21872230
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:14682109
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_001410721.2NP_001397650.1  golgin subfamily A member 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC097359
      Consensus CDS
      CCDS93242.1
      UniProtKB/TrEMBL
      H0Y6I0
      Related
      ENSP00000405842.2, ENST00000437131.2
    3. NM_001429190.1NP_001416119.1  golgin subfamily A member 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC097359
    4. NM_001429191.1NP_001416120.1  golgin subfamily A member 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC097359
      UniProtKB/TrEMBL
      A0A8V8TQI6
      Related
      ENSP00000514745.1, ENST00000699995.1
    5. NM_001429193.1NP_001416122.1  golgin subfamily A member 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC097359
    6. NM_001429196.1NP_001416125.1  golgin subfamily A member 4 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC097359
    7. NM_001429198.1NP_001416127.1  golgin subfamily A member 4 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC097359
    8. NM_001429201.1NP_001416130.1  golgin subfamily A member 4 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC097359
    9. NM_001429202.1NP_001416131.1  golgin subfamily A member 4 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC097359
    10. NM_002078.5NP_002069.2  golgin subfamily A member 4 isoform 2

      See identical proteins and their annotated locations for NP_002069.2

      Status: REVIEWED

      Source sequence(s)
      AW881112, BC045543, U41740
      Consensus CDS
      CCDS2666.1
      UniProtKB/Swiss-Prot
      F8W8Q7, Q13270, Q13439, Q13654, Q14436, Q59EW8
      Related
      ENSP00000354486.2, ENST00000361924.7
      Conserved Domains (4) summary
      PTZ00121
      Location:315997
      PTZ00121; MAEBL; Provisional
      smart00755
      Location:21722215
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:14462141
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:136452
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      37243271..37366879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447981.1XP_047303937.1  golgin subfamily A member 4 isoform X7

    2. XM_047447980.1XP_047303936.1  golgin subfamily A member 4 isoform X7

    3. XM_024453457.2XP_024309225.1  golgin subfamily A member 4 isoform X17

      Conserved Domains (3) summary
      smart00755
      Location:20532096
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      cl25732
      Location:13272022
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:196878
      Neuromodulin_N; Gap junction protein N-terminal region
    4. XM_005265069.4XP_005265126.1  golgin subfamily A member 4 isoform X1

      UniProtKB/TrEMBL
      C9J0Y3
      Related
      ENSP00000392907.2, ENST00000431105.2
      Conserved Domains (2) summary
      smart00755
      Location:22272270
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:15012196
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_005265070.4XP_005265127.1  golgin subfamily A member 4 isoform X2

      UniProtKB/TrEMBL
      A0A9L9PX25
      Related
      ENSP00000516454.1, ENST00000706569.1
      Conserved Domains (2) summary
      smart00755
      Location:22272270
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:15012196
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_005265071.4XP_005265128.1  golgin subfamily A member 4 isoform X3

      Conserved Domains (2) summary
      smart00755
      Location:22202263
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:15012142
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    7. XM_017006184.2XP_016861673.1  golgin subfamily A member 4 isoform X4

    8. XM_005265072.4XP_005265129.1  golgin subfamily A member 4 isoform X5

      Conserved Domains (2) summary
      smart00755
      Location:22112254
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:14852180
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    9. XM_006713110.3XP_006713173.1  golgin subfamily A member 4 isoform X8

      Conserved Domains (2) summary
      smart00755
      Location:21922235
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:14662161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    10. XM_005265074.2XP_005265131.1  golgin subfamily A member 4 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPI8
      Related
      ENSP00000514746.1, ENST00000699996.1
      Conserved Domains (2) summary
      smart00755
      Location:21872230
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:14682109
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    11. XM_047447985.1XP_047303941.1  golgin subfamily A member 4 isoform X13

    12. XM_017006188.2XP_016861677.1  golgin subfamily A member 4 isoform X16

    13. XM_011533598.4XP_011531900.1  golgin subfamily A member 4 isoform X18

      Conserved Domains (2) summary
      smart00755
      Location:17351778
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:10091704
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      37244671..37368411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346209.1XP_054202184.1  golgin subfamily A member 4 isoform X7

    2. XM_054346208.1XP_054202183.1  golgin subfamily A member 4 isoform X7

    3. XM_054346219.1XP_054202194.1  golgin subfamily A member 4 isoform X17

    4. XM_054346202.1XP_054202177.1  golgin subfamily A member 4 isoform X1

      UniProtKB/TrEMBL
      C9J0Y3
    5. XM_054346203.1XP_054202178.1  golgin subfamily A member 4 isoform X2

      UniProtKB/TrEMBL
      A0A9L9PX25
    6. XM_054346204.1XP_054202179.1  golgin subfamily A member 4 isoform X3

    7. XM_054346205.1XP_054202180.1  golgin subfamily A member 4 isoform X4

    8. XM_054346206.1XP_054202181.1  golgin subfamily A member 4 isoform X5

    9. XM_054346210.1XP_054202185.1  golgin subfamily A member 4 isoform X8

    10. XM_054346211.1XP_054202186.1  golgin subfamily A member 4 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPI8
    11. XM_054346215.1XP_054202190.1  golgin subfamily A member 4 isoform X13

    12. XM_054346218.1XP_054202193.1  golgin subfamily A member 4 isoform X16

    13. XM_054346220.1XP_054202195.1  golgin subfamily A member 4 isoform X18