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    TACC1 transforming acidic coiled-coil containing protein 1 [ Homo sapiens (human) ]

    Gene ID: 6867, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TACC1provided by HGNC
    Official Full Name
    transforming acidic coiled-coil containing protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11522
    See related
    Ensembl:ENSG00000147526 MIM:605301; AllianceGenome:HGNC:11522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ga55
    Summary
    This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TACC1 in Genome Data Viewer
    Location:
    8p11.22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38728582..38853028)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39005551..39130036)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38586100..38710546)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19131 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38508629-38509230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38508026-38508628 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:38546721-38547014 Neighboring gene uncharacterized LOC124901936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38558842-38559342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38577151-38577672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38591927-38592426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38593007-38593506 Neighboring gene Sharpr-MPRA regulatory region 10821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19136 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:38654374-38654912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27262 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:38664233-38664424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38692400-38693183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27263 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38718798-38719298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38719299-38719799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38721554-38722054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38722055-38722555 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:38724712-38725911 Neighboring gene uncharacterized LOC124901937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38771665-38772346 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38793869-38794549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38794550-38795229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27271 Neighboring gene Sharpr-MPRA regulatory region 15086 Neighboring gene HtrA serine peptidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Altered splicing pattern of TACC1 mRNA in gastric cancer. Line A, et al. Cancer Genet Cytogenet, 2002 Nov. PMID 12547166
    2. Temporal and spatial expression of TACC1 in the mouse and human. Lauffart B, et al. Dev Dyn, 2006 Jun. PMID 16496324
    3. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Gabillard JC, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531210
    4. Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma. Lv J, et al. Med Oncol, 2014 Nov. PMID 25297519
    5. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Still IH, et al. Oncogene, 1999 Jul 8. PMID 10435627

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis.
      Title: LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis.
    2. Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion.
      Title: Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion.
    3. The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients.
      Title: Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma.
    4. TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients.
      Title: Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer.
    5. These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer.
      Title: Efficient downregulation of ErbB-2 induces TACC1 upregulation in breast cancer cell lines.
    6. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
      Title: Transforming fusions of FGFR and TACC genes in human glioblastoma.
    7. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction.
      Title: Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
    9. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm.
      Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.
    10. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers.
      Title: Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42304, KIAA1103, DKFZp686K18126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear retinoic acid receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxisome proliferator activated receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 1
    Names
    gastric cancer antigen Ga55
    taxin-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122824.2 → NP_001116296.1  transforming acidic coiled-coil-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001116296.1

      Status: REVIEWED

      Source sequence(s)
      AY139007, AY177411, DB084271
      Consensus CDS
      CCDS47845.1
      UniProtKB/Swiss-Prot
      O75410
      Related
      ENSP00000276520.8, ENST00000276520.12
      Conserved Domains (1) summary
      pfam05010
      Location:189 → 388
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. NM_001146216.3 → NP_001139688.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 16-18, encodes isoform 3.
      Source sequence(s)
      AB029026, AC067817, AY072876, BX647696
      Consensus CDS
      CCDS55224.1
      UniProtKB/TrEMBL
      B4DHF7
      Related
      ENSP00000428450.1, ENST00000520615.5
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 603
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. NM_001330521.2 → NP_001317450.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 22-25, encodes isoform 4.
      Source sequence(s)
      AC067817, AI129797, BQ001033, DA152500, DA553264
      Consensus CDS
      CCDS83284.1
      UniProtKB/TrEMBL
      B4DH49, E7EVI4
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 574
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    4. NM_001352778.2 → NP_001339707.1  transforming acidic coiled-coil-containing protein 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (5).
      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:615 → 814
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    5. NM_001352779.2 → NP_001339708.1  transforming acidic coiled-coil-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:611 → 810
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    6. NM_001352780.2 → NP_001339709.1  transforming acidic coiled-coil-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:586 → 785
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    7. NM_001352781.2 → NP_001339710.1  transforming acidic coiled-coil-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:582 → 781
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    8. NM_001352782.2 → NP_001339711.1  transforming acidic coiled-coil-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:571 → 770
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    9. NM_001352783.2 → NP_001339712.1  transforming acidic coiled-coil-containing protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:570 → 769
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    10. NM_001352784.2 → NP_001339713.1  transforming acidic coiled-coil-containing protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS94286.1
      UniProtKB/TrEMBL
      E5RFM9
      Related
      ENSP00000430355.2, ENST00000522904.6
      Conserved Domains (1) summary
      pfam05010
      Location:542 → 741
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    11. NM_001352785.2 → NP_001339714.1  transforming acidic coiled-coil-containing protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:534 → 733
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    12. NM_001352786.2 → NP_001339715.1  transforming acidic coiled-coil-containing protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS87601.1
      Related
      ENSP00000428706.1, ENST00000518415.5
      Conserved Domains (1) summary
      pfam05010
      Location:525 → 724
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    13. NM_001352787.2 → NP_001339716.1  transforming acidic coiled-coil-containing protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:563 → 762
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    14. NM_001352788.2 → NP_001339717.1  transforming acidic coiled-coil-containing protein 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:416 → 615
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    15. NM_001352789.2 → NP_001339718.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 3, 17, and 18, encodes isoform 3.
      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS55224.1
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 603
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    16. NM_001352790.2 → NP_001339719.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 3, 16, and 18, encodes isoform 3.
      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS55224.1
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 603
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    17. NM_001352791.1 → NP_001339720.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 3, 16, and 17, encodes isoform 3.
      Source sequence(s)
      AC067817
      Consensus CDS
      CCDS55224.1
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 603
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    18. NM_001352792.2 → NP_001339721.1  transforming acidic coiled-coil-containing protein 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS87602.1
      UniProtKB/TrEMBL
      E7ET87, Q5HYH0
      Related
      ENSP00000428687.1, ENST00000519416.5
      Conserved Domains (1) summary
      pfam05010
      Location:403 → 602
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    19. NM_001352793.2 → NP_001339722.1  transforming acidic coiled-coil-containing protein 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variant 21, encodes isoform 17.
      Source sequence(s)
      AC016813, AC067817
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 602
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    20. NM_001352794.2 → NP_001339723.1  transforming acidic coiled-coil-containing protein 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 20, encodes isoform 17.
      Source sequence(s)
      AC016813, AC067817
      UniProtKB/TrEMBL
      B4DHF7
      Conserved Domains (1) summary
      pfam05010
      Location:404 → 602
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    21. NM_001352795.2 → NP_001339724.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 4 and 23-25, encodes isoform 4.
      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS83284.1
      UniProtKB/TrEMBL
      B4DH49, E7EVI4
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 574
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    22. NM_001352796.2 → NP_001339725.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 4, 22, 24, and 25, encodes isoform 4.
      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS83284.1
      UniProtKB/TrEMBL
      B4DH49, E7EVI4
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 574
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    23. NM_001352797.2 → NP_001339726.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 4, 22, 23, and 25, encodes isoform 4.
      Source sequence(s)
      AC016813, AC067817
      Consensus CDS
      CCDS83284.1
      UniProtKB/TrEMBL
      B4DH49, E7EVI4
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 574
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    24. NM_001352798.1 → NP_001339727.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 4 and 22-24, encodes isoform 4.
      Source sequence(s)
      AC067817
      Consensus CDS
      CCDS83284.1
      UniProtKB/TrEMBL
      B4DH49, E7EVI4
      Related
      ENSP00000430959.1, ENST00000520973.5
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 574
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    25. NM_001352799.2 → NP_001339728.1  transforming acidic coiled-coil-containing protein 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      UniProtKB/TrEMBL
      B4DH49
      Conserved Domains (1) summary
      pfam05010
      Location:375 → 573
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    26. NM_001352800.2 → NP_001339729.1  transforming acidic coiled-coil-containing protein 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC067817
      UniProtKB/TrEMBL
      R4GMT7

    27. NM_001352801.2 → NP_001339730.1  transforming acidic coiled-coil-containing protein 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:172 → 371
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    28. NM_001352802.1 → NP_001339731.1  transforming acidic coiled-coil-containing protein 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067817
      UniProtKB/TrEMBL
      B7Z3G3
      Related
      ENST00000522955.5

    29. NM_001352803.2 → NP_001339732.1  transforming acidic coiled-coil-containing protein 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:160 → 359
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    30. NM_001352804.2 → NP_001339733.1  transforming acidic coiled-coil-containing protein 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817
      Conserved Domains (1) summary
      pfam05010
      Location:132 → 331
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    31. NM_006283.3 → NP_006274.2  transforming acidic coiled-coil-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006274.2

      Status: REVIEWED

      Source sequence(s)
      AF049910, AY072876, AY139007, DB084271
      Consensus CDS
      CCDS6109.1
      UniProtKB/Swiss-Prot
      B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
      Related
      ENSP00000321703.4, ENST00000317827.9
      Conserved Domains (3) summary
      pfam05010
      Location:599 → 798
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:704 → 797
      FadA; Adhesion protein FadA
      cl21478
      Location:610 → 691
      ATP-synt_B; ATP synthase B/B' CF(0)

    RNA

    1. NR_148047.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813

    2. NR_148048.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813

    3. NR_148049.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817

    4. NR_148050.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817

    5. NR_148051.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813, AC067817

    6. NR_148052.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813

    7. NR_148053.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016813

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      38728582..38853028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422141.1 → XP_047278097.1  transforming acidic coiled-coil-containing protein 1 isoform X3

    2. XM_047422142.1 → XP_047278098.1  transforming acidic coiled-coil-containing protein 1 isoform X4

    3. XM_047422145.1 → XP_047278101.1  transforming acidic coiled-coil-containing protein 1 isoform X8

    4. XM_005273629.2 → XP_005273686.1  transforming acidic coiled-coil-containing protein 1 isoform X7

      Conserved Domains (3) summary
      pfam05010
      Location:575 → 774
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:680 → 773
      FadA; Adhesion protein FadA
      cl21478
      Location:586 → 667
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. XM_011544632.3 → XP_011542934.1  transforming acidic coiled-coil-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011542934.1

      UniProtKB/Swiss-Prot
      O75410
      Conserved Domains (1) summary
      pfam05010
      Location:611 → 810
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    6. XM_047422147.1 → XP_047278103.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    7. XM_047422140.1 → XP_047278096.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    8. XM_047422144.1 → XP_047278100.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    9. XM_005273625.5 → XP_005273682.1  transforming acidic coiled-coil-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005273682.1

      UniProtKB/Swiss-Prot
      O75410
      Conserved Domains (1) summary
      pfam05010
      Location:611 → 810
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    10. XM_047422149.1 → XP_047278105.1  transforming acidic coiled-coil-containing protein 1 isoform X10

      Related
      ENSP00000428253.1, ENST00000521866.5

    11. XM_047422138.1 → XP_047278094.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    12. XM_047422139.1 → XP_047278095.1  transforming acidic coiled-coil-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9

    13. XM_047422143.1 → XP_047278099.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    14. XM_047422148.1 → XP_047278104.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    15. XM_005273628.2 → XP_005273685.1  transforming acidic coiled-coil-containing protein 1 isoform X6

      Conserved Domains (3) summary
      pfam05010
      Location:583 → 782
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:688 → 781
      FadA; Adhesion protein FadA
      cl21478
      Location:594 → 675
      ATP-synt_B; ATP synthase B/B' CF(0)

    16. XM_047422146.1 → XP_047278102.1  transforming acidic coiled-coil-containing protein 1 isoform X9

    17. XM_047422150.1 → XP_047278106.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    18. XM_011544636.3 → XP_011542938.1  transforming acidic coiled-coil-containing protein 1 isoform X12

      UniProtKB/Swiss-Prot
      O75410
      Conserved Domains (2) summary
      pfam05010
      Location:161 → 360
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:271 → 359
      FadA; Adhesion protein FadA

    19. XM_047422151.1 → XP_047278107.1  transforming acidic coiled-coil-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      E7EVI4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      39005551..39130036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361089.1 → XP_054217064.1  transforming acidic coiled-coil-containing protein 1 isoform X3

    2. XM_054361090.1 → XP_054217065.1  transforming acidic coiled-coil-containing protein 1 isoform X4

    3. XM_054361095.1 → XP_054217070.1  transforming acidic coiled-coil-containing protein 1 isoform X8

    4. XM_054361093.1 → XP_054217068.1  transforming acidic coiled-coil-containing protein 1 isoform X7

    5. XM_054361087.1 → XP_054217062.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    6. XM_054361097.1 → XP_054217072.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    7. XM_054361088.1 → XP_054217063.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    8. XM_054361094.1 → XP_054217069.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    9. XM_054361086.1 → XP_054217061.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    10. XM_054361099.1 → XP_054217074.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    11. XM_054361084.1 → XP_054217059.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    12. XM_054361085.1 → XP_054217060.1  transforming acidic coiled-coil-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9

    13. XM_054361091.1 → XP_054217066.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    14. XM_054361098.1 → XP_054217073.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    15. XM_054361092.1 → XP_054217067.1  transforming acidic coiled-coil-containing protein 1 isoform X6

    16. XM_054361096.1 → XP_054217071.1  transforming acidic coiled-coil-containing protein 1 isoform X9

    17. XM_054361100.1 → XP_054217075.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    18. XM_054361102.1 → XP_054217077.1  transforming acidic coiled-coil-containing protein 1 isoform X12

    19. XM_054361101.1 → XP_054217076.1  transforming acidic coiled-coil-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      E7EVI4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75410.2 GenPept UniProtKB/Swiss-Prot:O75410

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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