Dnajc24 DnaJ heat shock protein family (Hsp40) member C24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc24provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C24provided by MGI
Primary source: MGI:MGI:1919522
See related: Ensembl:ENSMUSG00000027166 AllianceGenome:MGI:1919522
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dph4; Zcsl3; MmDjC7; 1700030A21Rik; 2610027M02Rik
Summary: Predicted to enable ATPase activator activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of ATP-dependent activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.3), CNS E14 (RPKM 6.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 55.46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (105797053..105833894, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (105966708..106003549, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mouse that was mutant for the gene, Dph4, was identified.
Title: Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 24

Names: CSL-type zinc finger-containing protein 3; DPH4 homolog (JJJ3, S. cerevisiae); DnaJ (Hsp40) homolog, subfamily C, member 24; diphthamide biosynthesis protein 4; j domain protein DjC7; zinc finger, CSL-type containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026992.3 → NP_081268.1 dnaJ homolog subfamily C member 24

See identical proteins and their annotated locations for NP_081268.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AK006521, AV331303

Consensus CDS

CCDS16501.1

UniProtKB/Swiss-Prot

Q91ZF0, Q9D9S7

Related

ENSMUSP00000099615.5, ENSMUST00000102555.11

Conserved Domains (2) summary

pfam00226
Location:10 → 78

DnaJ; DnaJ domain

pfam05207
Location:94 → 147

zf-CSL; CSL zinc finger

RNA

NR_033993.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK006521, AK011571, AV331303