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RHOBTB1 Rho related BTB domain containing 1 [ Homo sapiens (human) ]

Gene ID: 9886, updated on 27-Nov-2024

Summary

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Official Symbol
RHOBTB1provided by HGNC
Official Full Name
Rho related BTB domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18738
See related
Ensembl:ENSG00000072422 MIM:607351; AllianceGenome:HGNC:18738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues See more
Orthologs
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Genomic context

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See RHOBTB1 in Genome Data Viewer
Location:
10q21.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (60860860..61001967, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (61726193..61858729, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (62629196..62761198, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62495900-62496400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62496401-62496901 Neighboring gene ANK3 divergent transcript Neighboring gene cyclin dependent kinase 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62629619-62630120 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62630121-62630620 Neighboring gene uncharacterized LOC124902432 Neighboring gene RNA, U2 small nuclear 72, pseudogene Neighboring gene uncharacterized LOC124902431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2391 Neighboring gene uncharacterized LOC107984236 Neighboring gene Sharpr-MPRA regulatory region 5027 Neighboring gene uncharacterized LOC124902433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3395 Neighboring gene MPRA-validated peak951 silencer Neighboring gene long intergenic non-protein coding RNA 845 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:62795847-62796395 Neighboring gene uncharacterized LOC124902434

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B. McKinnon CM, et al. BMC Cancer, 2017 Feb 20. PMID 28219369, Free PMC Article
  2. Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. Beder LB, et al. J Cancer Res Clin Oncol, 2006 Jan. PMID 16170569
  3. Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination. Kumar G, et al. Function (Oxf), 2023. PMID 37575477, Free PMC Article
  4. The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. Xu RS, et al. Int J Oncol, 2013 Feb. PMID 23258531
  5. RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells. Long M, et al. Cells, 2020 Apr 28. PMID 32354068, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
    Title: Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
  2. RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
    Title: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
  3. RhoBTB1 associates with ROCK1 and ROCK2 and its association with ROCK1 is via its Rho domain.
    Title: RhoBTB1 interacts with ROCKs and inhibits invasion.
  4. RhoBTB1 regulates the integrity of the Golgi complex through METTL7B. RhoBTB1 is required for expression of METTL7B and silencing of either protein leads to fragmentation of the Golgi. Loss of RhoBTB1 expression is linked to Golgi fragmentation in breast cancer cells. Restoration of normal RhoBTB1 expression rescues Golgi morphology and dramatically inhibits breast cancer cell invasion.
    Title: The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.
  5. we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.
    Title: The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  7. Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).
    Title: Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0740, MGC33059, MGC33841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242359.2 → NP_001229288.1  rho-related BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001229288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AB018283, BC032848, BU624790, DA830304
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  2. NM_001350902.2 → NP_001337831.1  rho-related BTB domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB018283, AK075129, BC041791, BQ574439
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Related
    ENSP00000350595.4, ENST00000357917.4
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  3. NM_001350903.2 → NP_001337832.1  rho-related BTB domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC011197, BE046002, BQ574439, DA859805, DR004641
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  4. NM_001350904.2 → NP_001337833.1  rho-related BTB domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB018283, BC032848, BU624790, BX389628, DA830304, DR002604
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  5. NM_001350905.2 → NP_001337834.1  rho-related BTB domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB018283, BC032848, BU624790, DA793865, DA830304, DR002604
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  6. NM_001350906.2 → NP_001337835.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. NM_001350907.2 → NP_001337836.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC027678, BQ574439, DA781491, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  8. NM_001350908.2 → NP_001337837.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  9. NM_001350909.2 → NP_001337838.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC027678, AI935070, BC032848, BQ574439, DA930841, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  10. NM_001350910.2 → NP_001337839.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, BC032848, BQ574439, DA930841, DR002604, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. NM_001350911.2 → NP_001337840.1  rho-related BTB domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB018283, AC027678, BQ574439, DA793865, DA930841, DR004641
    Conserved Domains (3) summary
    smart00225
    Location:276 → 335
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:356 → 461
    BTB; BTB/POZ domain
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  12. NM_014836.5 → NP_055651.1  rho-related BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform. Variants 1-6 encode the same protein (isoform 1).
    Source sequence(s)
    AB018283, BC041791, BQ574439, DB453441
    Consensus CDS
    CCDS7261.1
    UniProtKB/Swiss-Prot
    O94844
    Related
    ENSP00000338671.5, ENST00000337910.10
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    60860860..61001967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426080.1 → XP_047282036.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  2. XM_047426086.1 → XP_047282042.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  3. XM_047426099.1 → XP_047282055.1  rho-related BTB domain-containing protein 1 isoform X2

  4. XM_047426092.1 → XP_047282048.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  5. XM_024448271.2 → XP_024304039.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  6. XM_011540425.2 → XP_011538727.1  rho-related BTB domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:17 → 208
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:486 → 583
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:476 → 578
    BTB; BTB/POZ domain
    cl02518
    Location:406 → 453
    BTB; BTB/POZ domain

  7. XM_011540424.2 → XP_011538726.1  rho-related BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538726.1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  8. XM_024448270.2 → XP_024304038.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  9. XM_047426083.1 → XP_047282039.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  10. XM_006718085.2 → XP_006718148.1  rho-related BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006718148.1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  11. XM_047426088.1 → XP_047282044.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  12. XM_047426082.1 → XP_047282038.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  13. XM_047426077.1 → XP_047282033.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  14. XM_047426078.1 → XP_047282034.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  15. XM_047426098.1 → XP_047282054.1  rho-related BTB domain-containing protein 1 isoform X2

  16. XM_047426095.1 → XP_047282051.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  17. XM_047426087.1 → XP_047282043.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  18. XM_047426091.1 → XP_047282047.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  19. XM_024448272.2 → XP_024304040.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  20. XM_047426097.1 → XP_047282053.1  rho-related BTB domain-containing protein 1 isoform X2

  21. XM_047426094.1 → XP_047282050.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  22. XM_047426074.1 → XP_047282030.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  23. XM_017017002.3 → XP_016872491.1  rho-related BTB domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:17 → 208
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:486 → 583
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:476 → 578
    BTB; BTB/POZ domain
    cl02518
    Location:406 → 453
    BTB; BTB/POZ domain

  24. XM_047426081.1 → XP_047282037.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  25. XM_047426096.1 → XP_047282052.1  rho-related BTB domain-containing protein 1 isoform X2

  26. XM_047426089.1 → XP_047282045.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  27. XM_047426090.1 → XP_047282046.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  28. XM_047426084.1 → XP_047282040.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  29. XM_047426075.1 → XP_047282031.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  30. XM_047426076.1 → XP_047282032.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  31. XM_047426093.1 → XP_047282049.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  32. XM_017017000.3 → XP_016872489.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  33. XM_047426079.1 → XP_047282035.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  34. XM_024448273.2 → XP_024304041.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18355
    Location:248 → 460
    BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18358
    Location:465 → 590
    BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cd18530
    Location:593 → 692
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

  35. XM_047426100.1 → XP_047282056.1  rho-related BTB domain-containing protein 1 isoform X3

  36. XM_011540428.2 → XP_011538730.1  rho-related BTB domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:17 → 208
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:396 → 455
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:406 → 453
    BTB; BTB/POZ domain

  37. XM_047426103.1 → XP_047282059.1  rho-related BTB domain-containing protein 1 isoform X4

  38. XM_047426104.1 → XP_047282060.1  rho-related BTB domain-containing protein 1 isoform X4

  39. XM_047426105.1 → XP_047282061.1  rho-related BTB domain-containing protein 1 isoform X4

  40. XM_047426102.1 → XP_047282058.1  rho-related BTB domain-containing protein 1 isoform X4

RNA

  1. XR_007062022.1 RNA Sequence

  2. XR_007062020.1 RNA Sequence

  3. XR_007062021.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    61726193..61858729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367310.1 → XP_054223285.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  2. XM_054367326.1 → XP_054223301.1  rho-related BTB domain-containing protein 1 isoform X2

  3. XM_054367316.1 → XP_054223291.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  4. XM_054367303.1 → XP_054223278.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  5. XM_054367323.1 → XP_054223298.1  rho-related BTB domain-containing protein 1 isoform X2

  6. XM_054367307.1 → XP_054223282.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  7. XM_054367312.1 → XP_054223287.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  8. XM_054367324.1 → XP_054223299.1  rho-related BTB domain-containing protein 1 isoform X2

  9. XM_054367296.1 → XP_054223271.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  10. XM_054367300.1 → XP_054223275.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  11. XM_054367301.1 → XP_054223276.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  12. XM_054367302.1 → XP_054223277.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  13. XM_054367299.1 → XP_054223274.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  14. XM_054367314.1 → XP_054223289.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  15. XM_054367308.1 → XP_054223283.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  16. XM_054367329.1 → XP_054223304.1  rho-related BTB domain-containing protein 1 isoform X2

  17. XM_054367322.1 → XP_054223297.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  18. XM_054367313.1 → XP_054223288.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  19. XM_054367318.1 → XP_054223293.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  20. XM_054367297.1 → XP_054223272.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  21. XM_054367328.1 → XP_054223303.1  rho-related BTB domain-containing protein 1 isoform X2

  22. XM_054367319.1 → XP_054223294.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  23. XM_054367295.1 → XP_054223270.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  24. XM_054367311.1 → XP_054223286.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  25. XM_054367320.1 → XP_054223295.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  26. XM_054367306.1 → XP_054223281.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  27. XM_054367325.1 → XP_054223300.1  rho-related BTB domain-containing protein 1 isoform X2

  28. XM_054367321.1 → XP_054223296.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  29. XM_054367327.1 → XP_054223302.1  rho-related BTB domain-containing protein 1 isoform X2

  30. XM_054367315.1 → XP_054223290.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  31. XM_054367317.1 → XP_054223292.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  32. XM_054367309.1 → XP_054223284.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  33. XM_054367298.1 → XP_054223273.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  34. XM_054367304.1 → XP_054223279.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  35. XM_054367305.1 → XP_054223280.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94844

  36. XM_054367330.1 → XP_054223305.1  rho-related BTB domain-containing protein 1 isoform X3

  37. XM_054367331.1 → XP_054223306.1  rho-related BTB domain-containing protein 1 isoform X4

  38. XM_054367332.1 → XP_054223307.1  rho-related BTB domain-containing protein 1 isoform X4

  39. XM_054367334.1 → XP_054223309.1  rho-related BTB domain-containing protein 1 isoform X4

  40. XM_054367335.1 → XP_054223310.1  rho-related BTB domain-containing protein 1 isoform X4

  41. XM_054367333.1 → XP_054223308.1  rho-related BTB domain-containing protein 1 isoform X4

RNA

  1. XR_008488314.1 RNA Sequence

  2. XR_008488315.1 RNA Sequence

  3. XR_008488316.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94844.2 GenPept UniProtKB/Swiss-Prot:O94844

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