Kmo kynurenine 3-monooxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kmoprovided by MGI
Official Full Name: kynurenine 3-monooxygenaseprovided by MGI
Primary source: MGI:MGI:2138151
See related: Ensembl:ENSMUSG00000039783 AllianceGenome:MGI:2138151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables kynurenine 3-monooxygenase activity. Involved in kynurenine metabolic process. Located in mitochondrial inner membrane. Is expressed in male reproductive gland or organ; nervous system; and tongue. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 28.0), kidney adult (RPKM 18.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 81.6 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (175459759..175488419)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (175632193..175660853)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kynurenine 3-monooxygenase limits de novo NAD[+] synthesis through dietary tryptophan in renal proximal tubule epithelial cell models.
Title: Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models.
Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington's disease.
Title: Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington's disease.
Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation.
Title: Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation.
The disproportionate kynurenic acid increase in the fetal brain of Kmo(+/-) animals indicates that the maternal Kmo genotype may play a key role in the pathophysiology of schizophrenia.
Title: Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
our study shows Kmonull mice had preserved renal function, reduced renal tubule cell injury and apoptosis, and fewer infiltrating neutrophils compared with Kmowt control mice.
Title: Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
Study shows that the development of depression-like behavior in the spared nerve injury model requires brain interleukin-1 signaling and activation of neuronal kynurenine 3-monoxygenase, while pain is independent of this pathway.
Title: Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.
results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders.
Title: Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders.
These results suggest that increased KP metabolites reduced chemokine production, resulting in suppressed mortality upon KMO knockdown in EMCV infection. KP metabolites may thus provide an effective strategy for treating acute viral myocarditis.
Title: Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
The findings of this study suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as Major depressive disorder model.
Title: Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes
Title: Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI046660 (e-PCR)
- UniSTS:158895

D1Mit403 (e-PCR), detects polymorphism
- UniSTS:128765

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables NAD(P)H oxidase H2O2-forming activity	ISO Inferred from Sequence Orthology more info
enables NAD(P)H oxidase H2O2-forming activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables kynurenine 3-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine 3-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kynurenine 3-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine 3-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in L-kynurenine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NAD metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NAD metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in anthranilate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in kynurenic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in kynurenic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in kynurenine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kynurenine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion, neurotransmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in response to salt stress	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: kynurenine 3-monooxygenase

Names: kynurenine 3-hydroxylase

NP_598570.1

EC 1.14.13.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133809.1 → NP_598570.1 kynurenine 3-monooxygenase

See identical proteins and their annotated locations for NP_598570.1

Status: PROVISIONAL

Source sequence(s)

BC014683

Consensus CDS

CCDS15548.1

UniProtKB/Swiss-Prot

Q91WN4

Related

ENSMUSP00000038914.9, ENSMUST00000040250.15

Conserved Domains (2) summary

COG0654
Location:10 → 361

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

cl21454
Location:11 → 330

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins