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B3galnt2 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 97884, updated on 27-Nov-2024

Summary

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Official Symbol
B3galnt2provided by MGI
Official Full Name
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2provided by MGI
Primary source
MGI:MGI:2145517
See related
Ensembl:ENSMUSG00000039242 AllianceGenome:MGI:2145517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930105D20Rik; D230016N13Rik
Summary
Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to act upstream of or within UDP-N-acetylgalactosamine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A11. Orthologous to human B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 13.6), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See B3galnt2 in Genome Data Viewer
Location:
13 A1; 13 5.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14129059..14173688)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13954474..13999103)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_33706 Neighboring gene STARR-seq mESC enhancer starr_33707 Neighboring gene zinc finger and BTB domain containing 7B pseudogene Neighboring gene tubulin-specific chaperone E Neighboring gene STARR-seq mESC enhancer starr_33708 Neighboring gene STARR-positive B cell enhancer ABC_E5369 Neighboring gene STARR-positive B cell enhancer ABC_E9866 Neighboring gene STARR-positive B cell enhancer ABC_E32 Neighboring gene geranylgeranyl diphosphate synthase 1 Neighboring gene AT-rich interaction domain 4B Neighboring gene predicted gene, 26129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc. Hiruma T, et al. J Biol Chem, 2004 Apr 2. PMID 14724282
  2. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC103263

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-N-acetylgalactosamine metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Names
beta-1,3-GalNAc-T2
beta-1,3-N-acetylgalactosaminyltransferase II
NP_001349333.1
NP_001349334.1
NP_848755.1
XP_006516881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362404.1 → NP_001349333.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AK151677, CT009546
    Consensus CDS
    CCDS26246.1
    UniProtKB/Swiss-Prot
    Q5U4F9, Q8BG28, Q8BXL0
    Related
    ENSMUSP00000152397.2, ENSMUST00000221974.2
    Conserved Domains (1) summary
    cl21608
    Location:330 → 459
    Galactosyl_T; Galactosyltransferase

  2. NM_001362405.1 → NP_001349334.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AK035259, AK151677
    Consensus CDS
    CCDS26246.1
    UniProtKB/Swiss-Prot
    Q5U4F9, Q8BG28, Q8BXL0
    Related
    ENSMUSP00000152755.2, ENSMUST00000221300.2
    Conserved Domains (1) summary
    cl21608
    Location:330 → 459
    Galactosyl_T; Galactosyltransferase

  3. NM_178640.3 → NP_848755.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

    See identical proteins and their annotated locations for NP_848755.1

    Status: VALIDATED

    Source sequence(s)
    CT009546
    Consensus CDS
    CCDS26246.1
    UniProtKB/Swiss-Prot
    Q5U4F9, Q8BG28, Q8BXL0
    Related
    ENSMUSP00000097336.4, ENSMUST00000099747.5
    Conserved Domains (1) summary
    cl21608
    Location:330 → 459
    Galactosyl_T; Galactosyltransferase

RNA

  1. NR_155555.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK084275, AK134868, AK151677

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    14129059..14173688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516818.3 → XP_006516881.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl21608
    Location:298 → 427
    Galactosyl_T; Galactosyltransferase

RNA

  1. XR_873137.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG28.1 GenPept UniProtKB/Swiss-Prot:Q8BG28

Gene LinkOut

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