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MTSS1 MTSS I-BAR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 9788, updated on 27-Nov-2024

Summary

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Official Symbol
MTSS1provided by HGNC
Official Full Name
MTSS I-BAR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20443
See related
Ensembl:ENSG00000170873 MIM:608486; AllianceGenome:HGNC:20443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIM; MIMA; MIMB
Summary
Enables actin monomer binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and renal tubule development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See MTSS1 in Genome Data Viewer
Location:
8q24.13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124550784..124728473, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125683798..125861532, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125563025..125740714, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27885 Neighboring gene microRNA 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19514 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27888 Neighboring gene uncharacterized LOC124902016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27889 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:125632749-125633948 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:125638519-125639718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27892 Neighboring gene Sharpr-MPRA regulatory region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27893 Neighboring gene Sharpr-MPRA regulatory region 2678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27895 Neighboring gene Sharpr-MPRA regulatory region 8202 Neighboring gene uncharacterized LOC105375741 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:125764038-125764579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125810571-125811072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125811073-125811572 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. Bompard G, et al. J Cell Sci, 2005 Nov 15. PMID 16280553
  2. Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of Human Bladder Uroepithelium Cell Carcinoma. Du P, et al. Anticancer Res, 2017 Aug. PMID 28739745
  3. Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. Wang H, et al. Acta Biochim Biophys Sin (Shanghai), 2017 Mar 1. PMID 28159994
  4. Loss of MTSS1 results in increased metastatic potential in pancreatic cancer. Zeleniak AE, et al. Oncotarget, 2017 Mar 7. PMID 28146435, Free PMC Article
  5. Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer. Zhao H, et al. Oncol Rep, 2016 Nov. PMID 27634022

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
    Title: The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
  2. Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
    Title: Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
  3. Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis.
    Title: Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
  4. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
    Title: MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
  5. Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
    Title: Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
  6. Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
    Title: Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
  7. Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
    Title: Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
  8. A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
    Title: A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
  9. MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
    Title: MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
  10. miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
    Title: miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44694, KIAA0429, DKFZp781P2223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in adherens junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glomerulus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microspike assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle TAS
Traceable Author Statement
more info
 PubMed 
located_in ruffle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein MTSS 1
Names
MTSS1, I-BAR domain containing
metastasis suppressor 1
metastasis suppressor YGL-1
metastasis suppressor protein 1
missing in metastasis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282971.2 → NP_001269900.1  protein MTSS 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090198, AJ710067, AK027015, DA790325
    Consensus CDS
    CCDS64969.1
    UniProtKB/TrEMBL
    A5YM41
    Related
    ENSP00000322804.5, ENST00000325064.9
    Conserved Domains (3) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330 → 729
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:728 → 758
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  2. NM_001282974.2 → NP_001269903.1  protein MTSS 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325, EF560715
    Consensus CDS
    CCDS64968.1
    UniProtKB/TrEMBL
    A5YM41
    Related
    ENSP00000367256.3, ENST00000378017.7
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:400 → 700
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:699 → 729
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  3. NM_001363294.2 → NP_001350223.1  protein MTSS 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, CN348724, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:723 → 749
    WH2; WH2 motif
    cl26464
    Location:325 → 724
    Atrophin-1; Atrophin-1 family

  4. NM_001363295.2 → NP_001350224.1  protein MTSS 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA447614, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326 → 708
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:707 → 737
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  5. NM_001363296.2 → NP_001350225.1  protein MTSS 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (3) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:404 → 704
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:703 → 733
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  6. NM_001363297.2 → NP_001350226.1  protein MTSS 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (4) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:567 → 695
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:702 → 728
    WH2; WH2 motif
    cl26464
    Location:403 → 703
    Atrophin-1; Atrophin-1 family

  7. NM_001363298.2 → NP_001350227.1  protein MTSS 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA225605, DA227466, DA785323, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (4) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:563 → 691
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:698 → 724
    WH2; WH2 motif
    cl26464
    Location:399 → 699
    Atrophin-1; Atrophin-1 family

  8. NM_001363299.2 → NP_001350228.1  protein MTSS 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:338 → 664
    Atrophin-1; Atrophin-1 family

  9. NM_001363300.2 → NP_001350229.1  protein MTSS 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:334 → 660
    Atrophin-1; Atrophin-1 family

  10. NM_001363301.2 → NP_001350230.1  protein MTSS 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:658 → 684
    WH2; WH2 motif
    cl26464
    Location:333 → 659
    Atrophin-1; Atrophin-1 family

  11. NM_001363302.2 → NP_001350231.1  protein MTSS 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:326 → 644
    Atrophin-1; Atrophin-1 family

  12. NM_014751.6 → NP_055566.3  protein MTSS 1 isoform 2

    See identical proteins and their annotated locations for NP_055566.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    Consensus CDS
    CCDS6353.1
    UniProtKB/Swiss-Prot
    J3KNK6, O43312, Q8TCA2, Q96RX2
    UniProtKB/TrEMBL
    A5YM41
    Related
    ENSP00000429064.1, ENST00000518547.6
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326 → 725
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:724 → 754
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    124550784..124728473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422493.1 → XP_047278449.1  protein MTSS 1 isoform X22

  2. XM_047422490.1 → XP_047278446.1  protein MTSS 1 isoform X18

  3. XM_017014086.3 → XP_016869575.1  protein MTSS 1 isoform X4

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:697 → 825
    Gag_spuma; Spumavirus gag protein

  4. XM_017014089.3 → XP_016869578.1  protein MTSS 1 isoform X8

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:672 → 800
    Gag_spuma; Spumavirus gag protein

  5. XM_017014092.3 → XP_016869581.1  protein MTSS 1 isoform X13

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:633 → 761
    Gag_spuma; Spumavirus gag protein

  6. XM_006716701.3 → XP_006716764.1  protein MTSS 1 isoform X3

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:698 → 826
    Gag_spuma; Spumavirus gag protein

  7. XM_017014088.3 → XP_016869577.1  protein MTSS 1 isoform X7

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:673 → 801
    Gag_spuma; Spumavirus gag protein

  8. XM_047422492.1 → XP_047278448.1  protein MTSS 1 isoform X20

  9. XM_006716704.3 → XP_006716767.1  protein MTSS 1 isoform X16

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:329 → 728
    PHA03247; large tegument protein UL36; Provisional

  10. XM_006716700.3 → XP_006716763.1  protein MTSS 1 isoform X2

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:701 → 829
    Gag_spuma; Spumavirus gag protein

  11. XM_006716706.3 → XP_006716769.1  protein MTSS 1 isoform X21

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:341 → 647
    PHA03247; large tegument protein UL36; Provisional

  12. XM_006716703.3 → XP_006716766.1  protein MTSS 1 isoform X15

    Conserved Domains (3) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330 → 756
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:620 → 748
    Gag_spuma; Spumavirus gag protein

  13. XM_005251113.3 → XP_005251170.1  protein MTSS 1 isoform X11

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:637 → 765
    Gag_spuma; Spumavirus gag protein

  14. XM_006716705.3 → XP_006716768.1  protein MTSS 1 isoform X17

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (3) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330 → 712
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:711 → 741
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  15. XM_006716702.3 → XP_006716765.1  protein MTSS 1 isoform X5

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:685 → 813
    Gag_spuma; Spumavirus gag protein

  16. XM_005251111.3 → XP_005251168.1  protein MTSS 1 isoform X1

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:702 → 830
    Gag_spuma; Spumavirus gag protein

  17. XM_017014087.3 → XP_016869576.1  protein MTSS 1 isoform X6

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    cd07643
    Location:7 → 241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:677 → 805
    Gag_spuma; Spumavirus gag protein

  18. XM_011517403.2 → XP_011515705.1  protein MTSS 1 isoform X12

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    pfam03276
    Location:635 → 763
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1 → 174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  19. XM_017014091.2 → XP_016869580.1  protein MTSS 1 isoform X10

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    pfam03276
    Location:639 → 767
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1 → 178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  20. XM_047422491.1 → XP_047278447.1  protein MTSS 1 isoform X19

    Related
    ENSP00000428319.1, ENST00000524090.5

  21. XM_017014090.3 → XP_016869579.1  protein MTSS 1 isoform X9

    UniProtKB/TrEMBL
    A5YM41
    Conserved Domains (2) summary
    pfam03276
    Location:647 → 775
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:15 → 186
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  22. XM_047422488.1 → XP_047278444.1  protein MTSS 1 isoform X14

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791784.1 Reference GRCh38.p14 PATCHES

    Range
    85734..103488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    125683798..125861532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361614.1 → XP_054217589.1  protein MTSS 1 isoform X22

  2. XM_054361610.1 → XP_054217585.1  protein MTSS 1 isoform X18

  3. XM_054361612.1 → XP_054217587.1  protein MTSS 1 isoform X20

  4. XM_054361608.1 → XP_054217583.1  protein MTSS 1 isoform X16

  5. XM_054361613.1 → XP_054217588.1  protein MTSS 1 isoform X21

  6. XM_054361609.1 → XP_054217584.1  protein MTSS 1 isoform X17

  7. XM_054361611.1 → XP_054217586.1  protein MTSS 1 isoform X19

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43312.2 GenPept UniProtKB/Swiss-Prot:O43312

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