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SECISBP2L SECIS binding protein 2 like [ Homo sapiens (human) ]

Gene ID: 9728, updated on 27-Nov-2024

Summary

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Official Symbol
SECISBP2Lprovided by HGNC
Official Full Name
SECIS binding protein 2 likeprovided by HGNC
Primary source
HGNC:HGNC:28997
See related
Ensembl:ENSG00000138593 MIM:615756; AllianceGenome:HGNC:28997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLAN; SBP2L
Summary
Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 34.5), lung (RPKM 24.8) and 25 other tissues See more
Orthologs
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Genomic context

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See SECISBP2L in Genome Data Viewer
Location:
15q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (48988638..49046446, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (46796860..46854692, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49280835..49338643, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9380 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49180996-49181177 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49204976-49206175 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:49237854-49239053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49254590-49255092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49255093-49255594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9381 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49267886-49268121 Neighboring gene keratin 8 pseudogene 24 Neighboring gene MPRA-validated peak2330 silencer Neighboring gene MPRA-validated peak2331 silencer Neighboring gene Sharpr-MPRA regulatory region 10237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9384 Neighboring gene RNA, 7SL, cytoplasmic 577, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:49357796-49358296 Neighboring gene uncharacterized LOC124903489 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49447830-49448748 Neighboring gene COP9 signalosome subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. Yu CT, et al. J Thorac Oncol, 2011 Jun. PMID 21566536
  2. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. Donovan J, et al. PLoS One, 2012. PMID 22530054, Free PMC Article
  3. Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of suppressed in lung cancer. Chiu SC, et al. Am J Physiol Cell Physiol, 2019 Sep 1. PMID 31314582
  4. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Franke FC, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30480076, Free PMC Article
  5. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev SI, et al. Invest Ophthalmol Vis Sci, 2003 Jun. PMID 12766061

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLAN mediates the Aurora-A-triggered cytokinesis bypass and SLAN plays dual roles in that process depending on its phosphorylation status.
    Title: Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of suppressed in lung cancer.
  2. SECISBP2L (SBP2L) interacts with all known human SECIS RNAs in vitro and selenoprotein mRNAs co-immunoprecipitate with endogenous SBP2L, suggesting a role in regulating selenoprotein expression.
    Title: Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.
  3. SLAN, also known as KIAA0256. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A.
    Title: The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
selenocysteine insertion sequence-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193489.2 → NP_001180418.1  selenocysteine insertion sequence-binding protein 2-like isoform 1

    See identical proteins and their annotated locations for NP_001180418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC008635, BC033001, BM129242, CD678675, D87445
    Consensus CDS
    CCDS53942.1
    UniProtKB/Swiss-Prot
    Q8N767, Q93073
    Related
    ENSP00000453854.1, ENST00000559471.6
    Conserved Domains (1) summary
    pfam01248
    Location:702 → 804
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

  2. NM_014701.4 → NP_055516.2  selenocysteine insertion sequence-binding protein 2-like isoform 2

    See identical proteins and their annotated locations for NP_055516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the CDS compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BM129242, CD678675, D87445, DA394911
    Consensus CDS
    CCDS32234.1
    UniProtKB/Swiss-Prot
    Q93073
    Related
    ENSP00000261847.3, ENST00000261847.7
    Conserved Domains (1) summary
    pfam01248
    Location:657 → 759
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    48988638..49046446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    46796860..46854692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93073.3 GenPept UniProtKB/Swiss-Prot:Q93073

Gene LinkOut

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