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SMAD5-AS1 SMAD5 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 9597, updated on 2-Nov-2024

Summary

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Official Symbol
SMAD5-AS1provided by HGNC
Official Full Name
SMAD5 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:30586
See related
Ensembl:ENSG00000164621 MIM:620035; AllianceGenome:HGNC:30586
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAMS; SMAD5AS; SMAD5OS
Summary
Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of BMP signaling pathway. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in skin (RPKM 1.2), liver (RPKM 0.3) and 16 other tissues See more
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Genomic context

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See SMAD5-AS1 in Genome Data Viewer
Location:
5q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (136129513..136134890, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136652045..136657420, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135465202..135470579, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23177 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:135388921-135390120 Neighboring gene transforming growth factor beta induced Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16378 Neighboring gene vault RNA 2-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23178 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:135488895-135490094 Neighboring gene SMAD family member 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:135527733-135528647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135528804-135529321 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:135537973-135538930 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:135538931-135539888 Neighboring gene small integral membrane protein 32 Neighboring gene TRPC7 antisense RNA 1 Neighboring gene transient receptor potential cation channel subfamily C member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of Long Non-coding RNA SMAD5-AS1 Reverses Epithelial Mesenchymal Transition in Nasopharyngeal Carcinoma via microRNA-195-Dependent Inhibition of SMAD5. Li S, et al. Front Oncol, 2019. PMID 31921616, Free PMC Article
  2. Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma. Zheng YJ, et al. FASEB J, 2019 Nov. PMID 31557058, Free PMC Article
  3. Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC. Zhao CC, et al. Cell Death Dis, 2019 Mar 15. PMID 30874550, Free PMC Article
  4. An antisense transcript to SMAD5 expressed in fetal and tumor tissues. Zavadil J, et al. Biochem Biophys Res Commun, 1999 Feb 24. PMID 10049768

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SMAD5-AS1 silencing suppressed epithelial-mesenchymal transition, cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC) by elevating miR-106a-5p to down-regulate SMAD5, which provided a novel therapeutic target for NPC treatment
    Title: Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma.
  2. SMAD5-AS1 inhibits diffuse large B cell lymphoma proliferation by sponging miR-135b-5p to up-regulate APC expression and inactivate classic Wnt/beta-catenin pathway.
    Title: Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

  • SMAD family member 5 opposite strand
  • SMAD family member 5, antisense
  • SMAD in the antisense orientation
  • SMAD5 antisense RNA 1 (non-protein coding)

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables miRNA inhibitor activity via base-pairing IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lncRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026763.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF071111
    Related
    ENST00000297163.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    136129513..136134890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136652045..136657420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022001.1: Suppressed sequence

    Description
    NM_022001.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6J3.1 GenPept UniProtKB/Swiss-Prot:Q9Y6J3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials