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fecR ferric citrate regulator FecR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949104, updated on 3-Dec-2024

Summary

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Official Symbol
fecR
Official Full Name
ferric citrate regulator FecR
Primary source
ECOCYC:EG10292
Locus tag
b4292
See related
ASAP:ABE-0014070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4282
Summary
Mutant has increased aggregation. [More information is available at EcoGene: EG10292]. FecARI are responsible for ferric citrate dependent induction of the ferric citrate uptake system. [More information is available at EcoCyc: EG10292].
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Genomic context

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Sequence:
NC_000913.3 (4516764..4517717, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate outer membrane transporter Neighboring gene RNA polymerase sigma factor FecI Neighboring gene protein YkiE Neighboring gene IS1 family repressor protein InsA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription induction of the ferric citrate transport genes via the N-terminus of the FecA outer membrane protein, the Ton system and the electrochemical potential of the cytoplasmic membrane. Kim I, et al. Mol Microbiol, 1997 Jan. PMID 9044267
  2. Ferric citrate transport of Escherichia coli: functional regions of the FecR transmembrane regulatory protein. Welz D, et al. J Bacteriol, 1998 May. PMID 9573190, Free PMC Article
  3. Residues involved in FecR binding are localized on one side of the FecA signaling domain in Escherichia coli. Breidenstein E, et al. J Bacteriol, 2006 Sep. PMID 16923915, Free PMC Article
  4. Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism. Passmore IJ, et al. J Bacteriol, 2020 Apr 9. PMID 32015149, Free PMC Article
  5. Transcription of the region encoding the ferric dicitrate-transport system in Escherichia coli: similarity between promoters for fecA and for extracytoplasmic function sigma factors. Enz S, et al. Gene, 1995 Sep 22. PMID 7557462

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism.
    Title: Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sigma factor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ferric citrate regulator FecR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4516764..4517717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418712.1 ferric citrate regulator FecR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418712.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5YHB9
    Conserved Domains (1) summary
    PRK09774
    Location:1 → 316
    PRK09774; fec operon regulator FecR; Reviewed
Nucleotide Protein
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