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rfe UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948789, updated on 17-Dec-2024

Summary

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Official Symbol
rfe
Official Full Name
UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
Primary source
ECOCYC:EG10840
Locus tag
b3784
See related
ASAP:ABE-0012366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3776; wecA
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Genomic context

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Sequence:
NC_000913.3 (3967916..3969019)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene rho operon leader peptide Neighboring gene transcription termination factor Rho Neighboring gene enterobacterial common antigen polysaccharide co-polymerase Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA. Al-Dabbagh B, et al. J Bacteriol, 2008 Nov. PMID 18723618, Free PMC Article
  2. Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide. Lehrer J, et al. J Bacteriol, 2007 Apr. PMID 17237164, Free PMC Article
  3. Preparative enzymatic synthesis of polyprenyl-pyrophosphoryl-N-acetylglucosamine, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope polymers. Al-Dabbagh B, et al. Anal Biochem, 2009 Aug 15. PMID 19442646
  4. Biosynthesis of enterobacterial common antigen in Escherichia coli. In vitro synthesis of lipid-linked intermediates. Barr K, et al. J Biol Chem, 1987 May 25. PMID 3034883
  5. The N-terminal region of the Escherichia coli WecA (Rfe) protein, containing three predicted transmembrane helices, is required for function but not for membrane insertion. Amer AO, et al. J Bacteriol, 2000 Jan. PMID 10629198, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An enzymatic assay of WecA was developed, and the kinetic parameters as well as the effects of pH, salts, cations, detergents, and temperature on the enzyme activity were determined. A minimal length of 35 carbons was required for the lipid substrate.
    Title: Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA.
  2. characterization of the functional roles of the conserved aspartic acids of WecA
    Title: Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide.
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General gene information

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Homology

General protein information

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Preferred Names
UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
NP_418231.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3967916..3969019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418231.1 UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418231.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DC17
    Conserved Domains (1) summary
    PRK15119
    Location:1 → 349
    PRK15119; UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
Nucleotide Protein
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