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tldE metalloprotease subunit TldE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948750, updated on 3-Dec-2024

Summary

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Official Symbol
tldE
Official Full Name
metalloprotease subunit TldE
Primary source
ECOCYC:EG10741
Locus tag
b4235
See related
ASAP:ABE-0013854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4230; mcb; pmbA
Summary
TldD and/or TldE act as a protease that is involved in sensitivity to DNA gyrase inhibitor LetD/CcdB (encoded by the F plasmid) by effecting degradation of the F plasmid-encoded LetD inhibitor, LetA/CcdA . [More information is available at EcoCyc: EG10741].
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Genomic context

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Sequence:
NC_000913.3 (4457959..4459311)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase Neighboring gene putative ribosome biogenesis factor YjgA Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase activating protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of the stationary phase-induced mcb operon promoter in Escherichia coli. Mao W, et al. Mol Microbiol, 1998 Jan. PMID 9484896
  2. Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance. Lomovskaya O, et al. Antimicrob Agents Chemother, 1996 Apr. PMID 8849229, Free PMC Article
  3. Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17. Rodríguez-Sáinz MC, et al. Mol Microbiol, 1990 Nov. PMID 2082149
  4. Factors influencing preferential utilization of RNA polymerase containing sigma-38 in stationary-phase gene expression in Escherichia coli. Kim EY, et al. J Microbiol, 2004 Jun. PMID 15357303
  5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
metalloprotease subunit TldE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4457959..4459311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418656.1 metalloprotease subunit TldE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418656.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6ZL35
    Conserved Domains (1) summary
    PRK11040
    Location:5 → 450
    PRK11040; peptidase PmbA; Provisional
Nucleotide Protein
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