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msrA methionine sulfoxide reductase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948734, updated on 3-Dec-2024

Summary

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Official Symbol
msrA
Official Full Name
methionine sulfoxide reductase A
Primary source
ECOCYC:EG11433
Locus tag
b4219
See related
ASAP:ABE-0013804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4215; pms; pmsR
Summary
MsrA exhibits methionine sulfoxide reductase activity in vitro (Km of 120 micromolar) . [More information is available at EcoCyc: EG11433].
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Genomic context

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Sequence:
NC_000913.3 (4441538..4442176, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene stringent response modulator YtfK Neighboring gene putative cadaverine/putrescine exporter Neighboring gene translocation and assembly module subunit TamA Neighboring gene translocation and assembly module subunit TamB Neighboring gene gamma-glutamylamine cyclotransferase family protein YtfP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing, and expression of the Escherichia coli peptide methionine sulfoxide reductase gene. Rahman MA, et al. J Biol Chem, 1992 Aug 5. PMID 1386361
  2. E. coli methionine sulfoxide reductase with a truncated N terminus or C terminus, or both, retains the ability to reduce methionine sulfoxide. Boschi-Muller S, et al. Protein Sci, 2001 Nov. PMID 11604533, Free PMC Article
  3. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. St John G, et al. Proc Natl Acad Sci U S A, 2001 Aug 14. PMID 11481433, Free PMC Article
  4. (1)H, (13)C and (15)N resonance assignment of the reduced form of methionine sulfoxide reductase A from Escherichia coli. Coudevylle N, et al. J Biomol NMR, 2004 Nov. PMID 15756465
  5. Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution. Tête-Favier F, et al. Structure, 2000 Nov 15. PMID 11080639

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that small RNA (sRNA) RyhB controls iron metabolism and directly pairs with the 5'UTR region of msrB at two distinct sites, but msrA expression is not sensitive to changes in iron availability.
    Title: The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Cloning, sequencing, and expression of the Escherichia coli peptide methionine sulfoxide reductase gene.
  3. MsrA and MsrB are required to repair Ffh oxidized by reactive oxygen species produced by aerobic metabolism, establishing an as-yet undescribed link between protein targeting and oxidation
    Title: Methionine sulfoxide reductases protect Ffh from oxidative damages in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-methionine-(S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-methionine-(S)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide-methionine (S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (S)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methionine sulfoxide reductase A
NP_418640.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4441538..4442176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418640.1 methionine sulfoxide reductase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418640.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JZP9
    Conserved Domains (1) summary
    PRK00058
    Location:1 → 212
    PRK00058; peptide-methionine (S)-S-oxide reductase MsrA
Nucleotide Protein
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