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dtpC dipeptide/tripeptide:H(+) symporter DtpC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948644, updated on 3-Dec-2024

Summary

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Official Symbol
dtpC
Official Full Name
dipeptide/tripeptide:H(+) symporter DtpC
Primary source
ECOCYC:EG12469
Locus tag
b4130
See related
ASAP:ABE-0013524
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4124; yjdL
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12469]. The YjdL protein is an uncharacterised member of the POT family of peptide transporters . [More information is available at EcoCyc: EG12469].
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Genomic context

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Sequence:
NC_000913.3 (4354954..4356411, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene toxin of the GhoTS toxin-antitoxin system Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene lysine decarboxylase 1 Neighboring gene lysine:cadaverine antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL. Jensen JM, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25261786
  2. DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli. Harder D, et al. FEBS J, 2008 Jul. PMID 18485005
  3. New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay. Prabhala BK, et al. FEBS Lett, 2014 Feb 14. PMID 24440353
  4. Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides. Ernst HA, et al. Biochem Biophys Res Commun, 2009 Nov 6. PMID 19703419
  5. Projection structure of DtpD (YbgH), a prokaryotic member of the peptide transporter family. Casagrande F, et al. J Mol Biol, 2009 Dec 11. PMID 19782088

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Lys117 interacts with the dipeptide carboxylate in proton-coupled oligopeptide transporter YjdL.
    Title: Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL.
  2. These results clearly indicate that unlike most proton-dependent oligopeptide transporters characterized to date, including YdgR and YhiP, YjdL shows significantly higher specificity towards dipeptides.
    Title: Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide:proton symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proton transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables tripeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tripeptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dipeptide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dipeptide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proton transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tripeptide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
dipeptide/tripeptide:H(+) symporter DtpC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4354954..4356411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418554.1 dipeptide/tripeptide:H(+) symporter DtpC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418554.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377B7L0
    Conserved Domains (1) summary
    cl28910
    Location:2 → 475
    MFS; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version

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