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melA alpha-galactosidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948636, updated on 3-Dec-2024

Summary

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Official Symbol
melA
Official Full Name
alpha-galactosidase
Primary source
ECOCYC:EG10577
Locus tag
b4119
See related
ASAP:ABE-0013493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4112; mel-7
Summary
Alpha-galactosidase was previously thought to be a tetramer, but is now believed to be a dimer. [More information is available at EcoCyc: EG10577].
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Genomic context

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Sequence:
NC_000913.3 (4341911..4343266)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene arginine decarboxylase, degradative Neighboring gene DNA-binding transcriptional dual regulator MelR Neighboring gene melibiose:H(+)/Na(+)/Li(+) symporter Neighboring gene DUF2238 domain-containing inner membrane protein YjdF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Melibiose permease and alpha-galactosidase of Escherichia coli: identification by selective labeling using a T7 RNA polymerase/promoter expression system. Pourcher T, et al. Biochemistry, 1990 Jan 23. PMID 2159786
  2. Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases. Legler G, et al. Carbohydr Res, 1986 Nov 1. PMID 3024831
  3. Nucleotide sequence of the melA gene, coding for alpha-galactosidase in Escherichia coli K-12. Liljeström PL, et al. Nucleic Acids Res, 1987 Mar 11. PMID 3031590, Free PMC Article
  4. Analysis of melibiose mutants deficient in alpha-galactosidase and thiomethylgalactoside permease II in Escherichia coli K-12. Schmitt R. J Bacteriol, 1968 Aug. PMID 4877127, Free PMC Article
  5. Alpha-galactosidase activity in cell-free extracts of Escherichia coli. Schmitt R, et al. Biochem Biophys Res Commun, 1966 Mar 8. PMID 5329906

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-galactosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-galactosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within melibiose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-galactosidase
NP_418543.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4341911..4343266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418543.1 alpha-galactosidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418543.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GHT3, A0A2H4TRS8, A0A8S7CP62
    Conserved Domains (1) summary
    PRK15076
    Location:4 → 449
    PRK15076; alpha-galactosidase; Provisional
Nucleotide Protein
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