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nrfC putative menaquinol-cytochrome c reductase 4Fe-4S subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948581, updated on 17-Dec-2024

Summary

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Official Symbol
nrfC
Official Full Name
putative menaquinol-cytochrome c reductase 4Fe-4S subunit
Primary source
ECOCYC:EG11946
Locus tag
b4072
See related
ASAP:ABE-0013346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4065; yjcJ
Summary
Verified Tat substrate: [More information is available at EcoGene: EG11946]. The nrfC gene encodes a transmembrane Fe-S protein, part of a nitrite reductase reaction, which may transfer electrons from the quinone pool to the c-type cytochromes or it may be an adapter that enables formate dehydrogenase H to transfer electrons into an electrogenic electron-transfer chain. [More information is available at EcoCyc: EG11946].
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Genomic context

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Sequence:
NC_000913.3 (4289808..4290479)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YtcB Neighboring gene cytochrome c552 nitrite reductase Neighboring gene periplasmic nitrite reductase penta-heme c-type cytochrome Neighboring gene putative menaquinol-cytochrome c reductase subunit NrfD Neighboring gene putative cytochrome c-type biogenesis protein NrfE Neighboring gene putative formate-dependent nitrite reductase complex subunit NrfF Neighboring gene putative formate-dependent nitrite reductase complex subunit NrfG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of a conserved glutamine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductase. Clarke TA, et al. Biochemistry, 2008 Mar 25. PMID 18311941
  2. The nitric oxide reductase activity of cytochrome c nitrite reductase from Escherichia coli. van Wonderen JH, et al. J Biol Chem, 2008 Apr 11. PMID 18245085
  3. Structure and spectroscopy of the periplasmic cytochrome c nitrite reductase from Escherichia coli. Bamford VA, et al. Biochemistry, 2002 Mar 5. PMID 11863430
  4. Respiratory detoxification of nitric oxide by the cytochrome c nitrite reductase of Escherichia coli. Poock SR, et al. J Biol Chem, 2002 Jun 28. PMID 11960983
  5. The Tat system proofreads FeS protein substrates and directly initiates the disposal of rejected molecules. Matos CF, et al. EMBO J, 2008 Aug 6. PMID 18615097, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrite reductase (cytochrome, ammonia-forming) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anaerobic electron transport chain RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
putative menaquinol-cytochrome c reductase 4Fe-4S subunit
NP_418496.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4289808..4290479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418496.1 putative menaquinol-cytochrome c reductase 4Fe-4S subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418496.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q7D7
    Conserved Domains (1) summary
    TIGR03149
    Location:2 → 223
    cyt_nit_nrfC; cytochrome c nitrite reductase, Fe-S protein
Nucleotide Protein
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