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ssb ssDNA-binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948570, updated on 3-Dec-2024

Summary

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Official Symbol
ssb
Official Full Name
ssDNA-binding protein
Primary source
ECOCYC:EG10976
Locus tag
b4059
See related
ASAP:ABE-0013298
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4051; exrB; lexC
Summary
SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). [More information is available at EcoGene: EG10976]. The product of the essential ssb gene, the highly stable single-stranded DNA binding protein SSB, is involved in replication, recombination, and repair in the DNA metabolism of Escherichia coli. [More information is available at EcoCyc: EG10976].
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Genomic context

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Sequence:
NC_000913.3 (4274125..4274661)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04237 family protein YjbR Neighboring gene UvrABC excision nuclease subunit A Neighboring gene uncharacterized protein YjcB Neighboring gene c-di-GMP phosphodiesterase PdeC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli single-stranded DNA-binding protein, a molecular tool for improved sequence quality in pyrosequencing. Ehn M, et al. Electrophoresis, 2002 Sep. PMID 12373756
  2. Characterization of the structural and functional defect in the Escherichia coli single-stranded DNA binding protein encoded by the ssb-1 mutant gene. Expression of the ssb-1 gene under lambda pL regulation. Williams KR, et al. J Biol Chem, 1984 Oct 10. PMID 6384214
  3. The product of the lexC gene of Escherichia coli is single-stranded DNA-binding protein. Meyer RR, et al. J Bacteriol, 1982 Apr. PMID 7037753, Free PMC Article
  4. SSB functions as a sliding platform that migrates on DNA via reptation. Zhou R, et al. Cell, 2011 Jul 22. PMID 21784244, Free PMC Article
  5. Mechanism of Exonuclease I stimulation by the single-stranded DNA-binding protein. Lu D, et al. Nucleic Acids Res, 2011 Aug. PMID 21572106, Free PMC Article

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA damage alters binding conformations of E. coli single-stranded DNA-binding protein.
    Title: DNA damage alters binding conformations of E. coli single-stranded DNA-binding protein.
  2. RecA and SSB genome-wide distribution in ssDNA gaps and ends in Escherichia coli.
    Title: RecA and SSB genome-wide distribution in ssDNA gaps and ends in Escherichia coli.
  3. Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli.
    Title: Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli.
  4. Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12.
    Title: Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12.
  5. DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication forks in Escherichia coli.
    Title: DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication forks in Escherichia coli.
  6. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
    Title: Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
  7. Multiprotein E. coli SSB-ssDNA complex shows both stable binding and rapid dissociation due to interprotein interactions.
    Title: Multiprotein E. coli SSB-ssDNA complex shows both stable binding and rapid dissociation due to interprotein interactions.
  8. RecA-SSB interaction should be included in discussing RecA regulatory mechanism.
    Title: RecA-SSB Interaction Modulates RecA Nucleoprotein Filament Formation on SSB-Wrapped DNA.
  9. SSB-AlkB interaction promotes faster repair of the methyl DNA adducts.
    Title: Escherichia coli single-stranded DNA binding protein SSB promotes AlkB-mediated DNA dealkylation repair.
  10. ExoI is primarily responsible for more efficiently abort template-switches on the lagging strand and that its ability to be recruited by single-strand DNA binding protein plays a critical role in quasipalindrome-associated mutagenesis avoidance and strand bias.
    Title: SSB recruitment of Exonuclease I aborts template-switching in Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in SOS response TAS
Traceable Author Statement
more info
 PubMed 
involved_in mismatch repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in recombinational repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of replisome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of single-stranded DNA-binding protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
ssDNA-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4274125..4274661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418483.1 ssDNA-binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418483.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0G4Q5
    Conserved Domains (1) summary
    PRK09010
    Location:1 → 178
    PRK09010; single-stranded DNA-binding protein; Provisional
Nucleotide Protein
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