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tatB twin arginine protein translocation system - TatB protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948319, updated on 14-Jan-2025

Summary

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Official Symbol
tatB
Official Full Name
twin arginine protein translocation system - TatB protein
Primary source
ECOCYC:G7808
Locus tag
b3838
See related
ASAP:ABE-0012545
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3831; mttA2; ysgB
Summary
Forms a complex with TatAC. [More information is available at EcoGene: EG14322]. TatB is a component of the TatABCE (twin-arginine translocation) complex for the export of folded proteins. [More information is available at EcoCyc: G7808].
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Genomic context

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Sequence:
NC_000913.3 (4022218..4022733)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ubiquinone biosynthesis accessory factor UbiJ Neighboring gene ncRNA Neighboring gene ubiquinone biosynthesis protein UbiB Neighboring gene twin arginine protein translocation system - TatA protein Neighboring gene twin arginine protein translocation system - TatC protein Neighboring gene 3' -> 5' ssDNA/RNA exonuclease TatD Neighboring gene transcription antiterminator RfaH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Twin-arginine translocase component TatB performs folding quality control via a chaperone-like activity. Taw MN, et al. Sci Rep, 2022 Sep 1. PMID 36050356, Free PMC Article
  2. Twin-arginine translocation-arresting protein regions contact TatA and TatB. Taubert J, et al. Biol Chem, 2014 Jul. PMID 25003386
  3. Initial assembly steps of a translocase for folded proteins. Blümmel AS, et al. Nat Commun, 2015 Jun 11. PMID 26068441, Free PMC Article
  4. Subunit interactions in the twin-arginine translocase complex of Escherichia coli. Bolhuis A, et al. FEBS Lett, 2000 Apr 21. PMID 10781811
  5. Cysteine-scanning mutagenesis and disulfide mapping studies of the conserved domain of the twin-arginine translocase TatB component. Lee PA, et al. J Biol Chem, 2006 Nov 10. PMID 16973610

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli.
    Title: TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli.
  2. Twin-arginine translocase component TatB performs folding quality control via a chaperone-like activity.
    Title: Twin-arginine translocase component TatB performs folding quality control via a chaperone-like activity.
  3. Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway.
    Title: Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway.
  4. It has been concluded that Tat signal peptides play roles in substrate targeting and in triggering assembly of the active TatABC translocase.
    Title: A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.
  5. In the TatBC receptor complex the transmembrane helix of each TatB molecule is sandwiched between two TatC molecules, with one of the inter-subunit interfaces incorporating a functionally important cluster of interacting polar residues. Unexpectedly, the authors find that TatA also associates with TatC at the polar cluster site.
    Title: Assembling the Tat protein translocase.
  6. In vitro cross-linking of residues located in the periplasmically-oriented part of the TatBC receptor to TorA[KQ]-30aa-MalE reporter variants harboring a more hydrophobic h-region in their signal peptides confirmed that unlike in TorA[KQ]-30aa-MalE with an unaltered h-region, the mutated reporters moved deep into the TatBC-binding cavity.
    Title: The h-region of twin-arginine signal peptides supports productive binding of bacterial Tat precursor proteins to the TatBC receptor complex.
  7. Twin-arginine translocation (Tat) system TatA exhibits a uniform distribution throughout the inner membrane and that altering the expression of TatBC shows a uncharacterised distribution of TatA in the inner membrane.
    Title: TatA complexes exhibit a marked change in organisation in response to expression of the TatBC complex.
  8. we confirm the evidence of interactions between TatC fragments and DmsD chaperone. Using a peptide overlapping array, it was shown that the different NarJ subfamily REMPs interact with different regions of the TatB cytoplasmic domains
    Title: Identification of protein-protein interactions between the TatB and TatC subunits of the twin-arginine translocase system and respiratory enzyme specific chaperones.
  9. Distributed TatA thus may serve to accompany membrane-interacting Tat substrates to the few TatBC spots in the cells.
    Title: TatBC-independent TatA/Tat substrate interactions contribute to transport efficiency.
  10. The data thus suggest that mature protein domains are translocated through a TatA and TaTB environment.
    Title: Twin-arginine translocation-arresting protein regions contact TatA and TatB.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proton motive force dependent protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport by the Tat complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport by the Tat complex IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport by the Tat complex NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of TAT protein transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TAT protein transport complex IEA
Inferred from Electronic Annotation
more info
  
part_of TAT protein transport complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
twin arginine protein translocation system - TatB protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4022218..4022733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026270.1 twin arginine protein translocation system - TatB protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026270.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GQ87
    Conserved Domains (1) summary
    PRK01770
    Location:1 → 171
    PRK01770; Sec-independent protein translocase subunit TatB
Nucleotide Protein
Heading Accession and Version

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